| 词条 | Teg49 small RNA |
| 释义 |
| Name = Teg49 sRNA | image = RF02696.svg | width = | caption = Predicted secondary structure and sequence conservation of Teg49 small RNA | Symbol = | AltSymbols = | Rfam = RF02696 | miRBase = | miRBase_family = | RNA_type = | Tax_domain = Bacteria | GO = {{GO|0009405}} | SO = {{SO|0000370}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }}Teg49 is a non-coding RNA present in the extended promoter region of the staphylococcal accessory regulator sarA. It was identified by RNA-seq and confirmed by Northern blot. It is modulated by sigB (sarA regulator[1]) and cshA (an ATP-dependant DEAD box RNA helicase[2]) and it most likely contributes to virulence of S. aureus by modulating SarA expression.[3] References1. ^{{Cite journal|last=Cheung|first=A. L.|last2=Chien|first2=Y. T.|last3=Bayer|first3=A. S.|date=1999-03-01|title=Hyperproduction of alpha-hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureus|journal=Infection and Immunity|volume=67|issue=3|pages=1331–1337|issn=0019-9567|pmc=96465|pmid=10024579}} {{DEFAULTSORT:Teg49 small rna}}{{molecular-cell-biology-stub}}2. ^{{Cite journal|last=Oun|first=Stella|last2=Redder|first2=Peter|last3=Didier|first3=Jean-Philippe|last4=François|first4=Patrice|last5=Corvaglia|first5=Anna-Rita|last6=Buttazzoni|first6=Elena|last7=Giraud|first7=Caroline|last8=Girard|first8=Myriam|last9=Schrenzel|first9=Jacques|date=2013-01-01|title=The CshA DEAD-box RNA helicase is important for quorum sensing control in Staphylococcus aureus|journal=RNA biology|volume=10|issue=1|pages=157–165|doi=10.4161/rna.22899|issn=1555-8584|pmc=3590232|pmid=23229022|url=https://archive-ouverte.unige.ch/unige:28414/ATTACHMENT01}} 3. ^{{Cite journal|last=Kim|first=Samin|last2=Reyes|first2=Dindo|last3=Beaume|first3=Marie|last4=Francois|first4=Patrice|last5=Cheung|first5=Ambrose|date=2014-10-01|title=Contribution of teg49 small RNA in the 5' upstream transcriptional region of sarA to virulence in Staphylococcus aureus|journal=Infection and Immunity|volume=82|issue=10|pages=4369–4379|doi=10.1128/IAI.02002-14|issn=1098-5522|pmc=4187880|pmid=25092913}} 1 : Non-coding RNA |
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