| 词条 | Tellurium ion resistance |
| 释义 |
The Tellurium Ion Resistance (TerC) Family (TC# 2.A.109) is part of the Lysine Exporter (LysE) Superfamily. A representative list of proteins belonging to the TerC family can be found in the Transporter Classification Database.[1] TerCThe TerC family (Pfam 03741) includes the E. coli TerC protein (TC# 2.A.109.1.1) which has been implicated in tellurium resistance.[2] It is hypothesized to catalyze efflux of tellurium ions.[2][3] TerC is encoded by plasmid pTE53 from a clinical isolate of E. coli. It has 346 amino acyl residues (aas) and 9 putative transmembrane segments (TMSs) with a large hydrophilic loop between TMSs 5 and 6.[2] A homologue in Arabidopsis thaliana (TC# 9.A.30.2.1) may function in prothylakoid membrane biogenises during early chloroplast development.[4] It has 384 aas and 7-8 putative TMSs. In E. coli, TerC forms a membrane complex with TerB as well as DctA, PspA, HslU, and RplK. The TerB/TerC complex may link different functional modules with biochemical activities of C4-dicarboxylate transport, inner membrane stress response (phage shock protein regulatory complex), ATPase/chaperone activity, and proteosynthesis.[5] It may be part of a metal sensing stress response system.[6] The co-presence of TerC and TerE but not TerF correlates with tellurite resistance when several hundred bacterial strains were assayed.[7] FunctionThe reaction proposed to be catalyzed by TerC is: tellurium ions (in) → tellurium ions (out). See also
Further reading
References1. ^{{Cite web| url = http://www.tcdb.org/search/result.php?tc=2.A.109.5| title = 2.A.109 The Tellurium Ion Resistance (TerC) Family| website = Transporter Classification Database| access-date = 2016-02-26}} {{Portal bar|Molecular and Cellular Biology|border=no}}{{membrane-protein-stub}}2. ^1 2 {{Cite journal| last = Burian| first = J.| last2 = Tu| first2 = N.| last3 = Kl'ucár| first3 = L.| last4 = Guller| first4 = L.| last5 = Lloyd-Jones| first5 = G.| last6 = Stuchlík| first6 = S.| last7 = Fejdi| first7 = P.| last8 = Siekel| first8 = P.| last9 = Turna| first9 = J.| date = 1998-01-01| title = In vivo and in vitro cloning and phenotype characterization of tellurite resistance determinant conferred by plasmid pTE53 of a clinical isolate of Escherichia coli| journal = Folia Microbiologica| volume = 43| issue = 6| pages = 589–599| issn = 0015-5632| pmid = 10069007| doi=10.1007/bf02816374}} 3. ^{{Cite journal| last = Kormutakova| first = R.| last2 = Klucar| first2 = L.| last3 = Turna| first3 = J.| date = 2000-06-01| title = DNA sequence analysis of the tellurite-resistance determinant from clinical strain of Escherichia coli and identification of essential genes| journal = BioMetals| volume = 13| issue = 2| pages = 135–139| issn = 0966-0844| pmid = 11016400}} 4. ^{{Cite journal|last=Kwon|first=Kwang-Chul|last2=Cho|first2=Myeon Haeng|date=2008-08-01|title=Deletion of the chloroplast-localized AtTerC gene product in Arabidopsis thaliana leads to loss of the thylakoid membrane and to seedling lethality|journal=The Plant Journal|volume=55|issue=3|pages=428–442|doi=10.1111/j.1365-313X.2008.03523.x|issn=1365-313X|pmid=18429937}} 5. ^{{Cite journal|last=Turkovicova|first=L.|last2=Smidak|first2=R.|last3=Jung|first3=G.|last4=Turna|first4=J.|last5=Lubec|first5=G.|last6=Aradska|first6=J.|date=2016-01-09|title=Proteomic analysis of the TerC interactome: Novel links to tellurite resistance and pathogenicity|journal=Journal of Proteomics|doi=10.1016/j.jprot.2016.01.003|issn=1876-7737|pmid=26778143|volume=136|pages=167–73}} 6. ^{{Cite journal|last=Anantharaman|first=Vivek|last2=Iyer|first2=Lakshminarayan M.|last3=Aravind|first3=L.|date=2012-10-30|title=Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing|journal=Molecular BioSystems|volume=8|issue=12|pages=3142–3165|doi=10.1039/c2mb25239b|issn=1742-2051|pmc=4104200|pmid=23044854}} 7. ^{{Cite journal|last=Orth|first=Dorothea|last2=Grif|first2=Katharina|last3=Dierich|first3=Manfred P.|last4=Würzner|first4=Reinhard|date=2007-03-01|title=Variability in tellurite resistance and the ter gene cluster among Shiga toxin-producing Escherichia coli isolated from humans, animals and food|journal=Research in Microbiology|volume=158|issue=2|pages=105–111|doi=10.1016/j.resmic.2006.10.007|issn=0923-2508|pmid=17317110}} 7 : Biology|Protein families|Membrane proteins|Transmembrane proteins|Transmembrane transporters|Transport proteins|Integral membrane proteins |
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