| 词条 | Testifenon |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = [(5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] 2-[4-[bis(2-chloroethyl)amino]phenyl]acetate | image = Testifenon.svg | width = 250px | image2 = Testifenon molecule ball.png | width2 = 250px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 104730-58-7 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 128659 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 114020 | UNII = | KEGG = | ChEBI = | ChEMBL = | synonyms = Testiphenon; Testiphenone; Chlorphenacyl dihydrotestosterone ester; Dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate; LS-19378 | C=31 | H=43 | Cl=2 | N=1 | O=3 | SMILES = C[C@]12CCC(=O)C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4OC(=O)CC5=CC=C(C=C5)N(CCCl)CCCl)C | StdInChI_Ref = | StdInChI = 1S/C31H43Cl2NO3/c1-30-13-11-24(35)20-22(30)5-8-25-26-9-10-28(31(26,2)14-12-27(25)30)37-29(36)19-21-3-6-23(7-4-21)34(17-15-32)18-16-33/h3-4,6-7,22,25-28H,5,8-20H2,1-2H3/t22-,25-,26-,27-,28-,30-,31-/m0/s1 | StdInChIKey_Ref = | StdInChIKey = JWLXQUMDRGJLMS-SJQIPMMSSA-N }}Testifenon, also known as testiphenon, testiphenone, chlorphenacyl dihydrotestosterone ester, or dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic anabolic–androgenic steroid (AAS) and a cytostatic antineoplastic agent (i.e., chemotherapeutic) that was never marketed.[1][2][3] It is an androgen ester – specifically, a chlorphenacyl nitrogen mustard ester of dihydrotestosterone (DHT) – and acts as a prodrug of these two components in the body.[1][2] The drug was developed in Russia as a tissue-selective cytostatic drug for the treatment of various cancers occurring in androgen receptor-expressing tissues that would have reduced side effects and toxicity relative to other chemotherapy drugs.[1][2] See also
References1. ^1 2 {{cite journal | vauthors = Lagova ND, Sof'ina ZP, Shkodinskaia EN, Kurdiumova KN, Valueva IM | title = [The antineoplastic activity of testiphenon] | language = Russian | journal = Vopr Onkol | volume = 34 | issue = 11 | pages = 1363–8 | year = 1988 | pmid = 3201773 | doi = | url = }} {{Androgen receptor modulators}}{{Steroid-stub}}{{Antineoplastic-drug-stub}}2. ^1 2 {{cite journal|last1=Demidova|first1=N. V.|last2=Serebryakova|first2=E. A.|last3=Gasan-Guseinova|first3=Z. G.|last4=Zimakova|first4=N. I.|last5=Arzamastsev|first5=A. P.|title=Comparative pharmacokinetics of3H-testiphenone and3H-chlorophenacyl in peroral administration to mice|journal=Pharmaceutical Chemistry Journal|volume=29|issue=11|year=1995|pages=737–739|issn=0091-150X|doi=10.1007/BF02331848}} 3. ^{{cite journal | vauthors = Oborotova NA, Smirnova ZS, Polozkova ZS, Baryshnikov AI | title = [Pharmacological aspects in the development of liposomal medicinal preparations for the internal injection of hydrophobic cytostatics] | language = Russian | journal = Vestn. Akad. Med. Nauk SSSR | volume = | issue = 1 | pages = 42–5 | year = 2002 | pmid = 11882971 | doi = | url = }} 9 : Abandoned drugs|Androgens and anabolic steroids|Androstanes|Antineoplastic drugs|Dihydrotestosterone esters|Nitrogen mustards|Organochlorides|Prodrugs|Russian drugs |
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