| 词条 | Tezacaftor |
| 释义 |
| drug_name = | INN = | type = | IUPAC_name = 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide | image = Tezacaftor.svg | alt = 200px | caption = | pronounce = | tradename = Symdeko (with ivacaftor) | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = | pregnancy_category= | routes_of_administration = | legal_AU = | legal_AU_comment = | legal_BR = | legal_BR_comment = | legal_CA = | legal_DE = | legal_NZ = | legal_UK = | legal_US = | legal_UN = | legal_status = | bioavailability = | protein_bound = | metabolism = | metabolites = | onset = | elimination_half-life = | duration_of_action = | excretion = | CAS_number = 1152311-62-0 | UNII = 8RW88Y506K | class = | ATCvet = | ATC_prefix = | ATC_suffix = | PubChem = 46199646 | DrugBank = DB11712 | KEGG = D11041 | C=26|H=27|F=3|N=2|O=6 }} Tezacaftor, also known as VX-661, is a drug approved by the FDA to treat some cases of cystic fibrosis. In 2018, the FDA approved a combination of ivacaftor and tezacaftor; the manufacturer announced a list price of $292,000 per year.[1] The combination of ivacaftor and tezacaftor is being sold as Symdeko.[2] Mechanism of actionTezacaftor helps move the CFTR protein to the correct position on the cell surface, and is designed to treat people with the F508del mutation.[3] PropertiesIts chemical formula is C26H27F3N2O6, with a molecular weight of 520.505 g/mol.[4] Clinical trialsThe EVOLVE and EXPAND study findings were published in 2017.[2] References1. ^[https://www.bostonglobe.com/business/2018/02/12/fda-approves-another-vertex-drug-for-treatment-cystic-fibrosis/uU5Jfnirrwv57kH1aj2W5N/story.html FDA approves another Vertex drug for treatment of cystic fibrosis] {{pharma-stub}}2. ^1 [https://www.medpagetoday.com/pulmonology/cysticfibrosis/71125 FDA Approves New Cystic Fibrosis Drug Combo - Symdeko approved for patients with specific CFTR mutations Feb 2018] 3. ^[https://cysticfibrosisnewstoday.com/tezacaftor-vx-661-for-cystic-fibrosis Tezacaftor (VX-661) for Cystic Fibrosis] 4. ^[https://pubchem.ncbi.nlm.nih.gov/compound/vx-661#section=Top Tezacaftor] includes structure 4 : Benzodioxoles|Cyclopropanes|Indoles|Organofluorides |
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