| 词条 | Thea Tlsty |
| 释义 |
| honorific_prefix = | name = Thea D Tlsty | honorific_suffix = | image = | image_size = | image_upright = | alt = | caption = | birth_name = | birth_date = | birth_place = | death_date = | death_place = | death_cause = | resting_place = | resting_place_coordinates = | citizenship = | nationality = American | fields = | workplaces = {{Plainlist|
| patrons = | education = | alma_mater = University of South Florida | thesis_title = | thesis_url = | thesis_year = | doctoral_advisor = | academic_advisors = | doctoral_students = | notable_students = | known_for = Breast cancer research | influences = | influenced = | awards = | spouse = | partner = | children = | signature = | signature_alt = | website = | footnotes = }}Thea D. Tlsty, PhD, is Professor of Pathology at the University of California, San Francisco.[1] She is known for her research in cancer biology, and her involvement in the discovery of cells that may be at the origin of metaplastic cancer, an invasive form of breast cancer.[2] EducationTlsty gained a Bachelor of Science degree in Zoology from the University of South Florida, Tampa (1973). She started a PhD in Molecular Biology at the University of North Carolina, Chapel Hill, which she completed in 1980 after transferring to Washington University in St. Louis.[2] ResearchTlsty led an eight-year research study, published in the Journal of the National Cancer Institute in 2010, which established a means to predict whether women with early stage breast cancer might develop more serious tumours, using "biomarkers" (biological indicators in the body) to determine cancer risk.[3][4] Tlsty also led research into 'pluripotent' stem cells in breast tissue, seeking to identify if these caused tumours.[5] This research had looked at wound cells in breast tissue, and identified 'repair cells' that could transform into a range of other cells, including neurons, bone and cartilage[6][7] - with the potential therefore to also treat cancers and other diseases.[8][9] In 2015 she co-authored research into the use of 3D tissue culture models to study breast cancer cell generation,[10] and later collaborated with Adam Engler of the University of California, San Diego in developing devices to test how strongly cells attach to tumour tissue, exploring if adhesion strength could be an accurate marker of metastatic cells.[11] Tlsty was awarded a 2019 Cancer Research UK Grand Challenge award to support a research project in collaboration with scientists from the UK, Canada, and Israel.[12] The project will focus on understanding how chronic inflammation contributes to cancer.[13][14][15] References1. ^{{Cite web|url=http://pathology.ucsf.edu/about/faculty/pathology-ttlsty.html|title=UCSF Departments of Pathology and Laboratory Medicine {{!}} About {{!}} Faculty {{!}} Thea Tlsty, PhD|website=pathology.ucsf.edu|access-date=2019-03-07}} {{authority control}}{{DEFAULTSORT:Tlsty, Thea}}2. ^1 {{Cite web|url=http://cancer.ucsf.edu/people/profiles/tlsty_thea.3688|title=Thea D. Tlsty, PhD {{!}} UCSF Helen Diller Family Comprehensive Cancer Center|website=cancer.ucsf.edu|access-date=2019-03-07}} 3. ^{{cite news |last1=Allday |first1=Erin |title=UCSF find predicts severity of breast cancer |url=https://www.sfgate.com/health/article/UCSF-find-predicts-severity-of-breast-cancer-3191090.php |accessdate=8 March 2019 |work=SFGate |date=29 April 2010}} 4. ^{{Cite journal|last=Kerlikowske, K|first=Tlsty T|date=2010-05-05|title=Biomarker Expression and Risk of Subsequent Tumors After Initial Ductal Carcinoma In Situ Diagnosis|journal=Journal of the National Cancer Institute|volume=102|issue=9|pages=627–637|doi=10.1093/jnci/djq101|pmc=2864293|pmid=20427430 }} 5. ^{{cite news |title=Rare somatic cells from human breast tissue exhibit extensive lineage plasticity |url=https://www.pnas.org/content/early/2013/02/27/1218682110 |accessdate=8 March 2019 |work=PNAS |publisher=PNAS |date=4 March 2013}} 6. ^{{cite news |last1=Hughes |first1=Virginia |title=Cells That Don’t Belong |url=https://www.nationalgeographic.com/science/phenomena/2013/07/10/cells-that-dont-belong/ |accessdate=8 March 2019 |work=National Geographic |date=10 July 2013}} 7. ^{{cite news |last1=Heaven |first1=Douglas |title=Are breast milk stem cells the real deal for medicine? |url=https://www.newscientist.com/article/mg21729084-800-are-breast-milk-stem-cells-the-real-deal-for-medicine/ |accessdate=8 March 2019 |work=New Scientist |date=13 March 2013}} 8. ^{{cite news |last1=Leuty |first1=Ron |title=UCSF discovery a potential "earthquake" for stem cell therapies |url=https://www.bizjournals.com/sanfrancisco/blog/biotech/2013/03/new-stem-cells-ucsf-tlsty-embryonic-cirm.html |accessdate=8 March 2019 |work=San Francisco Business Times |date=4 March 2013}} 9. ^{{cite news |last1=Hughes |first1=Virginia |title=The Rise of the Multi-Talented Adult Stem Cell |url=https://www.smithsonianmag.com/science-nature/the-rise-of-the-multi-talented-adult-stem-cell-4492929/#Tabula-Rasa-illustration-2.jpg |accessdate=8 March 2019 |work=Smithsonian |date=July 2013}} 10. ^{{cite journal |title=Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization |journal=Scientific Reports |date=16 October 2015 |volume=5 |url=https://www.nature.com/articles/srep15153 |accessdate=8 March 2019}} 11. ^{{cite news |title=Cell 'stickiness' could indicate metastatic potential |url=https://phys.org/news/2017-02-cell-stickiness-metastatic-potential.html |accessdate=8 March 2019 |work=Phys.Org |date=February 28, 2017}} 12. ^{{Cite web|url=https://www.cancerresearchuk.org/our-research/researchers/professor-thea-tlsty|title=Professor Thea Tlsty|date=2019-01-23|website=Cancer Research UK|language=en|access-date=2019-03-07}} 13. ^{{Cite web|url=http://cancer.ucsf.edu/news/2019/01/29/q-a-with-thea-tlsty-phd-on-leading-international-team-to-study-inflammation-and-cancer.9365|title=Q & A with Thea Tlsty, PhD, on Leading International Team to Study Inflammation and Cancer {{!}} UCSF Helen Diller Family Comprehensive Cancer Center|website=cancer.ucsf.edu|access-date=2019-03-07}} 14. ^[https://endpts.com/microbiome-inflammation-and-mutations-us-researchers-win-60m-in-cancer-research-uk-grants-to-lead-grand-challenges/ "Microbiome, inflammation and mutations: US researchers win £60M in Cancer Research UK grants to lead 'grand challenges'"], Endpoint News 15. ^[https://www.cancerresearchuk.org/about-us/cancer-news/press-release/2019-01-23-cancer-research-uk-tackles-global-cancer-challenges-with-ps60-million-in-funding "Cancer Research UK tackles global cancer challenges with £60 million in funding"], Cancer Research UK 7 : Living people|Cancer researchers|American molecular biologists|Women molecular biologists|University of California, San Francisco faculty|University of South Florida alumni|Year of birth missing (living people) |
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