“Amine dehydrogenase”的意思、由来-开放百科全书

词条

Amine dehydrogenase

释义

References
External links

{{Enzyme
| Name = Amine dehydrogenase
| EC_number = 1.4.99.3
| CAS_number = 60496-14-2
| IUBMB_EC_number = 1/4/99/3
| GO_code =
| image =
| width =
| caption =
}}

Amine Dehydrogenase ({{EC number|1.4.99.3}}), also known as methylamine dehydrogenase (MADH), is a tryptophan tryptophylquinone-dependent (TTQ-dependent) enzyme that catalyzes the oxidative deamination of a primary amine to an aldehyde and ammonia. The reaction occurs as follows:

RCH₂NH₂ + H₂O + acceptor → RCHO + NH₃ + reduced acceptor

Amine dehydrogenase possesses an α₂β₂ structure with each smaller β subunit possessing a TTQ protein cofactor.

Amine dehydrogenase, studied in Paracoccus denitrificans, at least transiently forms a ternary complex to catalyze methylamine-dependent cytochrome c-551i reduction. Within this complex, electrons are transferred from the TTQ cofactor of MADH to the Type 1 copper center of amicyanin, and then to the heme of the cytochrome.

References

{{cite journal | vauthors = Davidson VL | title = Electron transfer in quinoproteins | journal = Archives of Biochemistry and Biophysics | volume = 428 | issue = 1 | pages = 32–40 | date = August 2004 | pmid = 15234267 | doi = 10.1016/j.abb.2004.03.022 }}

External links

{{MeshName|methylamine+dehydrogenase}}

1 : EC 1.4.99

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。