| 词条 | Tic110 family |
| 释义 |
The Chloroplast Envelope Anion Channel-forming Tic110 (Tic110) Family (TC#1.A.18) consists of proteins of the inner chloroplast envelope membrane. This family consists of the inner membrane protein import apparatus, and appears to be a protein import-related anion-selective channel. It has also been designated (1) IEP110, (2) IAP100 and (3) protein import-related anion channel (PIRAC). LocationMost of the Tic110 protein is probably in the intermembrane space.[1] Transport across the outer and inner membranes probably occurs by two independent processes.[2] StructureArabidopsis thaliana Tic 110 is 996 amino acyl residues long and exhibits 2 putative transmembrane segments (TMSs) near its N-terminus at positions 74-92 and 101-120. Biochemical analyses suggest that this protein is part of a 600 kDa complex. Tic110 has two proposed functions with naturally exclusive structures; a protein-conducting channel with 6 TMSs, and a scaffold with 2 N-terminal TMSs followed by a large soluble domain for binding transit peptides and other stromal translocon components. The C-terminal half of Tic110 possesses a rod-shaped helix-repeat structure that is too flattened and elongated to be a channel. The structure is most similar to the HEAT-repeat motif that functions as scaffolds for protein-protein interactions.[3] The pore size was estimated to be about 6.5 Å.[4]Transport ReactionThe transport reactions across the chloroplast inner membrane catalyzed by Tic110 are: (1) anions (out) ⇌ anions (in) (2) proteins (out) → proteins (in) References1. ^{{Cite journal|last=Lübeck|first=J.|last2=Soll|first2=J.|last3=Akita|first3=M.|last4=Nielsen|first4=E.|last5=Keegstra|first5=K.|date=1996-08-15|title=Topology of IEP110, a component of the chloroplastic protein import machinery present in the inner envelope membrane|journal=The EMBO Journal|volume=15|issue=16|pages=4230–4238|issn=0261-4189|pmc=452148|pmid=8861951}} {{CCBYSASource|sourcepath=http://www.tcdb.org/search/result.php?tc=1.a.18|sourcearticle=1.A.18 The Chloroplast Envelope Anion Channel-forming Tic110 (Tic110) Family|revision=699838558}}2. ^{{Cite journal|last=Kessler|first=F.|last2=Blobel|first2=G.|date=1996-07-23|title=Interaction of the protein import and folding machineries of the chloroplast|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=93|issue=15|pages=7684–7689|issn=0027-8424|pmc=38807|pmid=8755536|doi=10.1073/pnas.93.15.7684}} 3. ^{{Cite journal|last=Tsai|first=Jia-Yin|last2=Chu|first2=Chiung-Chih|last3=Yeh|first3=Yi-Hung|last4=Chen|first4=Lih-Jen|last5=Li|first5=Hsou-Min|last6=Hsiao|first6=Chwan-Deng|date=2013-09-01|title=Structural characterizations of the chloroplast translocon protein Tic110|journal=The Plant Journal|volume=75|issue=5|pages=847–857|doi=10.1111/tpj.12249|issn=1365-313X|pmc=3823011|pmid=23711301}} 4. ^{{Cite journal|last=van den Wijngaard|first=P. W.|last2=Vredenberg|first2=W. J.|date=1999-09-03|title=The envelope anion channel involved in chloroplast protein import is associated with Tic110|journal=The Journal of Biological Chemistry|volume=274|issue=36|pages=25201–25204|issn=0021-9258|pmid=10464239|doi=10.1074/jbc.274.36.25201}} 6 : Protein families|Membrane proteins|Transmembrane proteins|Transmembrane transporters|Transport proteins|Integral membrane proteins |
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