| 词条 | Amsacrine |
| 释义 |
| verifiedrevid = 457129529 | IUPAC_name = N-(4-(acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide | image = Amsacrine.svg | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 00DPD30SOY | smiles = O=S(=O)(Nc1ccc(c(OC)c1)Nc2c4c(nc3c2cccc3)cccc4)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C21H19N3O3S/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13,24H,1-2H3,(H,22,23) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = XCPGHVQEEXUHNC-UHFFFAOYSA-N | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 51264-14-3 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 43 | ATC_prefix = L01 | ATC_suffix = XX01 | ATC_supplemental = | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 2687 | PubChem = 2179 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2094 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB00276 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D02321 | C=21 | H=19 | N=3 | O=3 | S=1 | molecular_weight = 393.46 g/mol | bioavailability = | protein_bound = 96 to 98% | metabolism = | elimination_half-life = 8–9 hours | excretion = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_UK = | legal_US = | legal_status = | routes_of_administration = }} Amsacrine (synonyms: m-AMSA, acridinyl anisidide) is an antineoplastic agent. It has been used in acute lymphoblastic leukemia.[1] MechanismIts planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove proportions. These alterations to DNA structure inhibit both DNA replication and transcription by reducing association between the affected DNA and: DNA polymerase, RNA polymerase and transcription factors. Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II (compares with the better known agent etoposide).[2] In contrast, the structurally similar o-AMSA differing in the position of the methoxy substituent group on the anilino-ring have little ability to poison topoisomerase II despite of its intercalative behavior, suggesting that intercalation of the molecule in itself is insufficient to trap topoisomerase II as a covalent complex on DNA.[3][4][5] References1. ^{{cite journal | pmid = 16330449 | volume=90 | issue=12 | title=Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children |date=December 2005 | journal=Haematologica | pages=1701–3}} {{Chemotherapeutic agents}}{{antineoplastic-drug-stub}}2. ^Genetic Response to Metals. Sarkar, Bibudhendra. CRC Press, 1995. {{ISBN|978-0-8247-9615-0}} 3. ^{{cite journal | pmid = 2602146 | pmc=335223 | volume=17 | issue=23 | title=Thermodynamics of the interactions of m-AMSA and o-AMSA with nucleic acids: influence of ionic strength and DNA base composition |date=December 1989 | journal=Nucleic Acids Res. | pages=9933–46 | doi=10.1093/nar/17.23.9933}} 4. ^{{cite journal | pmid = 2830452 | volume=2 | issue=5 | title=Mutagenicity of m-AMSA and o-AMSA in mammalian cells due to clastogenic mechanism: possible role of topoisomerase |date=September 1987 | journal=Mutagenesis | pages=349–55 | doi=10.1093/mutage/2.5.349}} 5. ^{{cite journal | doi = 10.1038/nrc2607 | pmid = 19377506 | pmc=2748742 | volume=9 | issue=5 | title=Targeting DNA topoisomerase II in cancer chemotherapy |date=May 2009 | journal=Nat. Rev. Cancer | pages=338–50}} 7 : Sulfonamides|Antineoplastic drugs|IARC Group 2B carcinogens|Acridines|O-Methylated phenols|DNA intercalaters|Topoisomerase inhibitors |
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