| 词条 | TLQP-62 |
| 释义 |
|Name= VGF nerve growth factor inducible |caption= |image= |width= |HGNCid=12684 |Symbol=VGF |AltSymbols= |EntrezGene=7425 |OMIM=602186 |RefSeq=NM_003378 |UniProt=O15240 |PDB= |ECnumber= |Chromosome=7 |Arm=q |Band=22 |LocusSupplementaryData= }} TLQP-62 (amino acid 556-617) is a VGF-derived C-terminal peptide that was first discovered by Trani et al.[1] TLQP-62 is derived from VGF precursor protein via proteolytic cleavage by prohormone convertases PC1/3 at the RPR555 site.[2] TLQP-62 is named after its first four N-terminal amino acids and its peptide length. FunctionAlthough the receptor(s) for TLQP-62 has not been identified so far, extensive studies have demonstrated that it acts on central nervous system, peripheral nervous system and endocrine tissue to exert its biological functions. Synaptic plasticityAcute TLQP-62 treatment rapidly increases synaptic activity in hippocampal neurons,[3] and potentiates CA1 field excitatory postsynaptic potential fEPSP in the hippocampal slices,[4] thus facilitating hippocampal synaptic transmission. TLQP-62 also increases dendritic branching and length in cultured hippocampal neurons.[5] NeurogenesisTLQP-62 treatment enhances hippocampal neurogenesis both in vitro and in vivo[6] by promoting the proliferation in neuronal progenitor cells.[7] Antidepressant efficacyIntrahippocampal TLQP-62 infusion produces both rapid and sustained antidepressant-like effects in the forced swim test.[8][9] TLQP-62's processed peptide AQEE-30, when given via intracerebroventricular route, also elicits antidepressant-like effects.[10] Memory and learningAcute intrahippocampal TLQP-62 infusion enhances memory formation via BDNF/TrkB signaling.[11] PainAcute intrathecal administration of TLQP-62 induces hypersensitivity to mechanical and cold stimuli that recapitulates neuropathic pain, potentially by regulating the excitability of dorsal horn neurons.[12] Insulin secretionTLQP-62 treatment increases insulin secretion in cultured insulinoma cells by increasing intracellular calcium mobilization.[13] References1. ^{{cite journal | vauthors = Trani E, Ciotti T, Rinaldi AM, Canu N, Ferri GL, Levi A, Possenti R | title = Tissue-specific processing of the neuroendocrine protein VGF | journal = Journal of Neurochemistry | volume = 65 | issue = 6 | pages = 2441–9 | date = December 1995 | pmid = 7595538 | doi = 10.1046/j.1471-4159.1995.65062441.x }} 2. ^{{cite journal | vauthors = Trani E, Giorgi A, Canu N, Amadoro G, Rinaldi AM, Halban PA, Ferri GL, Possenti R, Schininà ME, Levi A | title = Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor | journal = Journal of Neurochemistry | volume = 81 | issue = 3 | pages = 565–74 | date = May 2002 | pmid = 12065665 | doi = 10.1046/j.1471-4159.2002.00842.x }} 3. ^{{cite journal | vauthors = Alder J, Thakker-Varia S, Bangasser DA, Kuroiwa M, Plummer MR, Shors TJ, Black IB | title = Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity | journal = The Journal of Neuroscience | volume = 23 | issue = 34 | pages = 10800–8 | date = November 2003 | pmid = 14645472 | pmc = 3374594 | url = http://www.jneurosci.org/content/jneuro/23/34/10800.full.pdf }} 4. ^{{cite journal | vauthors = Bozdagi O, Rich E, Tronel S, Sadahiro M, Patterson K, Shapiro ML, Alberini CM, Huntley GW, Salton SR | title = The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism | journal = The Journal of Neuroscience | volume = 28 | issue = 39 | pages = 9857–69 | date = September 2008 | pmid = 18815270 | doi = 10.1523/jneurosci.3145-08.2008 | pmc = 2820295 }} 5. ^{{cite journal | vauthors = Behnke J, Cheedalla A, Bhatt V, Bhat M, Teng S, Palmieri A, Windon CC, Thakker-Varia S, Alder J | title = Neuropeptide VGF Promotes Maturation of Hippocampal Dendrites That Is Reduced by Single Nucleotide Polymorphisms | journal = International Journal of Molecular Sciences | volume = 18 | issue = 3 | pages = 612 | date = March 2017 | pmid = 28287464 | doi = 10.3390/ijms18030612 }} 6. ^{{cite journal | vauthors = Thakker-Varia S, Krol JJ, Nettleton J, Bilimoria PM, Bangasser DA, Shors TJ, Black IB, Alder J | title = The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus | journal = The Journal of Neuroscience | volume = 27 | issue = 45 | pages = 12156–67 | date = November 2007 | pmid = 17989282 | doi = 10.1523/JNEUROSCI.1898-07.2007 }} 7. ^{{cite journal | vauthors = Thakker-Varia S, Behnke J, Doobin D, Dalal V, Thakkar K, Khadim F, Wilson E, Palmieri A, Antila H, Rantamaki T, Alder J | title = VGF (TLQP-62)-induced neurogenesis targets early phase neural progenitor cells in the adult hippocampus and requires glutamate and BDNF signaling | journal = Stem Cell Research | volume = 12 | issue = 3 | pages = 762–77 | date = May 2014 | pmid = 24747217 | doi = 10.1016/j.scr.2014.03.005 }} 8. ^{{cite journal | vauthors = Thakker-Varia S, Krol JJ, Nettleton J, Bilimoria PM, Bangasser DA, Shors TJ, Black IB, Alder J | title = The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus | journal = The Journal of Neuroscience | volume = 27 | issue = 45 | pages = 12156–67 | date = November 2007 | pmid = 17989282 | doi = 10.1523/jneurosci.1898-07.2007 }} 9. ^{{cite journal | vauthors = Jiang C, Lin WJ, Sadahiro M, Labonté B, Menard C, Pfau ML, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR | title = VGF function in depression and antidepressant efficacy | journal = Molecular Psychiatry | date = November 2017 | pmid = 29158577 | doi = 10.1038/mp.2017.233 }} 10. ^{{cite journal | vauthors = Hunsberger JG, Newton SS, Bennett AH, Duman CH, Russell DS, Salton SR, Duman RS | title = Antidepressant actions of the exercise-regulated gene VGF | journal = Nature Medicine | volume = 13 | issue = 12 | pages = 1476–82 | date = December 2007 | pmid = 18059283 | doi = 10.1038/nm1669 }} 11. ^{{cite journal | vauthors = Lin WJ, Jiang C, Sadahiro M, Bozdagi O, Vulchanova L, Alberini CM, Salton SR | title = VGF and Its C-Terminal Peptide TLQP-62 Regulate Memory Formation in Hippocampus via a BDNF-TrkB-Dependent Mechanism | journal = The Journal of Neuroscience | volume = 35 | issue = 28 | pages = 10343–56 | date = July 2015 | pmid = 26180209 | doi = 10.1523/JNEUROSCI.0584-15.2015 | pmc = 4502270 }} 12. ^{{cite journal | vauthors = Moss A, Ingram R, Koch S, Theodorou A, Low L, Baccei M, Hathway GJ, Costigan M, Salton SR, Fitzgerald M | title = Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury | journal = Molecular Pain | volume = 4 | pages = 62 | date = December 2008 | pmid = 19077191 | doi = 10.1186/1744-8069-4-62 }} 13. ^{{cite journal | vauthors = Petrocchi-Passeri P, Cero C, Cutarelli A, Frank C, Severini C, Bartolomucci A, Possenti R | title = The VGF-derived peptide TLQP-62 modulates insulin secretion and glucose homeostasis | journal = Journal of Molecular Endocrinology | volume = 54 | issue = 3 | pages = 227–39 | date = June 2015 | pmid = 25917832 | doi = 10.1530/jme-14-0313 }} 1 : Peptides |
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