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词条 Amylmetacresol
释义

  1. See also

  2. References

  3. External links

{{Drugbox
| verifiedrevid = 443857623
| IUPAC_name = 5-Methyl-2-pentylphenol
| image = Amylmetacresol.svg
| width = 175
| tradename =
| Drugs.com = {{drugs.com|international|hexylresorcinol}}
| pregnancy_category =
| legal_status = OTC
| routes_of_administration = By mouth
| bioavailability =
| metabolism =
| excretion =
| CAS_number_Ref =
| CAS_number = 53043-14-4
| ATC_prefix = R02
| ATC_suffix = AA20
| PubChem = 14759
| ChEMBL = 1512677
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 14076
| UNII_Ref =
| UNII =
| KEGG_Ref =
| KEGG =
| C=12 | H=18 | O=1
| molecular_weight = 178.27
| smiles = CCCCCC1=C(C=C(C=C1)C)O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C12H18O/c1-3-4-5-6-11-8-7-10(2)9-12(11)13/h7-9,13H,3-6H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = CKGWFZQGEQJZIL-UHFFFAOYSA-N
}}{{Refimprove|date=December 2009}}

Amylmetacresol (AMC) is an antiseptic used to treat infections of the mouth and throat. It is used as an active pharmaceutical ingredient in Strepsils, Cēpacol, Gorpils and Lorsept throat lozenges.

Chemically, AMC is derivative of m-cresol, with a pentyl group attached to the sixth carbon atom. The pure substance melts at 24 °C, and boils between 137 to 139 °C (at 6.7 kPa). It is soluble in water, ethanol, acetone, ether, and oil. AMC exhibits low toxicity, and a RW coefficient of 250.[1]

See also

  • 2,4-Dichlorobenzyl alcohol
  • Hexylresorcinol
  • Cetylpyridinium chloride
  • Dequalinium

References

1. ^{{cite journal | last=Twort | first=CC | author2=Baker, AH | year = 1942 | title=Further Researches on Bactericidal Mists and Smokes | journal=The Journal of Hygiene | pages=266–283 | volume=42 | issue=3 | pmc=2199819 | pmid=20475630 | doi=10.1017/s0022172400035476}}

External links

  • {{cite journal |author=C. E. Coulthard |date=1931 |title=The Disinfectant and Antiseptic Properties of Amyl-meta-cresol |journal=J Exp Patho |volume=12 |issue=5 |pages=331–336 |pmc=2048245 }}
  • {{cite journal |vauthors=Oxford JS, Lambkin R, Gibb I, Balasingam S, Chan C, Catchpole A |date=2005 |title=A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV |journal=Antivir Chem Chemother |volume=16 |issue=2 |pages=129–34 |pmid=15889535 |doi=10.1177/095632020501600205}}
  • {{cite journal |vauthors=McNally D, Shephard A, Field E |date=2012 |title=Randomised, double-blind, placebo-controlled study of a single dose of an amylmetacresol/2,4-dichlorobenzyl alcohol plus lidocaine lozenge or a hexylresorcinol lozenge for the treatment of acute sore throat due to upper respiratory tract infection |journal=J Pharm Pharm Sci |volume=15 |issue=2 |pages=281–94 |pmid=22579007 |doi=10.18433/j31309}}
  • {{cite journal |vauthors=Weckmann G, Hauptmann-Voß A, Baumeister SE, Klötzer C, Chenot JF |date=2017 |title=Efficacy of AMC/DCBA lozenges for sore throat: A systematic review and meta-analysis |journal=Int J Clin Pract |volume=71 |issue=10 |pages=1742-1241 |pmid=28869700 |doi=10.1111/ijcp.13002}}
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2 : Antiseptics|Alkylphenols

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