“TOG superfamily”的意思、由来-开放百科全书

词条

TOG superfamily

释义

Families
Structures
See also
References
Further reading

The transporter-opsin-G protein-coupled receptor (TOG) superfamily is a protein superfamily of integral membrane proteins, usually of 7 or 8 transmembrane alpha-helical segments (TMSs). It includes (1) ion-translocating microbial rhodopsins and (2) G protein-coupled receptors (GPCRs), (3) Sweet sugar transporters, (4) nicotinamide ribonucleoside uptake permeases (PnuC; TC# 4.B.1), (5) 4-toluene sulfonate uptake permeases (TSUP); TC# 2.A.102), (6) Ni²⁺–Co²⁺ transporters (NiCoT); TC# 2.A.52), (7) organic solute transporters (OST); TC# 2.A.82), (8) phosphate:Na⁺ symporters (PNaS); TC# 2.A.58) and (9) lysosomal cystine transporters (LCT); TC# 2.A.43).^[1] ^[2]

Families

Currently recognized families within the TOG Superfamily (with TC numbers in blue) include:^[3]

1.A.14 - The Testis-enhanced Gene Transfer (TEGT) Family
1.A.26 - The Mg²⁺ Transporter-E (MgtE) Family
1.A.76 - The Magnesium Transporter1 (MagT1) Family
2.A.43 - The Lysosomal Cystine Transporter (LCT) Family
2.A.52 - The Ni²⁺-Co²⁺ Transporter (NiCoT) Family
2.A.58 - The Phosphate:Na⁺ Symporter (PNaS) Family
2.A.82 - The Organic Solute Transporter (OST) Family
2.A.102 - The 4-Toluene Sulfonate Uptake Permease (TSUP) Family
2.A.123 - The Sweet; PQ-loop; Saliva; MtN3 (Sweet) Family
3.E.1 - The Ion-translocating Microbial Rhodopsin (MR) Family
4.B.1 - The Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) Family
9.A.14 - The G-protein-coupled receptor (GPCR) Family

Structures

A couple of the 3-D structures available for members of the following families include:

SWEET family: {{PDB2|4RNG}}
MR family: {{PDB2|5AX0}}, {{PDB2|3T45}} - high resolution structures
PnuC family: {{PDB2|4QTN}}
GPCR family: {{PDB2|3CAP}}

References

1. ^{{cite journal |author1=Maksim A. Shlykov |author2=Wei Hao Zheng |author3=Jonathan S. Chen |author4=Milton H. Saier, Jr.. |last-author-amp=yes | title = Bioinformatic Characterization of the 4-Toluene Sulfonate Uptake Permease (TSUP) Family of Transmembrane Proteins. | journal = Biochimica et Biophysica Acta | volume = 1818 | issue = 3 | pages = 703–717 | date=March 2012 | pmc =3917603| doi = 10.1016/j.bbamem.2011.12.005| pmid=22192777}}
2. ^{{cite journal | author =Yee DC1, Shlykov MA, Västermark A, Reddy VS, Arora S, Sun EI, Saier MH Jr.. | title = The transporter-opsin-G protein-coupled receptor (TOG) superfamily. | journal = The FEBS Journal | volume = 280 | issue = 22 | pages = 5780–5800 |date=September 2013 | pmid = 23981446| doi = 10.1111/febs.12499 | pmc=3832197}}
3. ^{{cite web|last1=Saier|first1=Milton|title=Transporter-Opsin-G protein-coupled receptor (TOG) Superfamily|url=http://www.tcdb.org/superfamily.php?id=58|website=tcdb.org|accessdate=28 December 2015}}

Families

Structures

See also

References

Further reading