| 词条 | Tosagestin |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = (1S,2R,10R,11S,14R,15S)-14-ethynyl-14-hydroxy-15-methyl-17-methylidenetetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-6,12-dien-5-one | image = Tosagestin.svg | width = | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = By mouth | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 110072-15-6 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | PubChem = 159355 | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 140146 | UNII = YS7Z529O22 | ChEMBL = 2107658 | KEGG = D06197 | synonyms = ORG-30659; Exogestin; Letogestin;[1] 11-Methylene-δ15-norethisterone; 17α-Ethynyl-11-methylene-19-nor-δ15-testosterone | C=21 | H=24 | O=2 | molecular_weight = 308.41406 g/mol | SMILES = CC12CC(=C)C3C(C1C=CC2(C#C)O)CCC4=CC(=O)CCC34 | StdInChI_Ref = | StdInChI = 1S/C21H24O2/c1-4-21(23)10-9-18-17-7-5-14-11-15(22)6-8-16(14)19(17)13(2)12-20(18,21)3/h1,9-11,16-19,23H,2,5-8,12H2,3H3/t16-,17-,18-,19+,20-,21-/m0/s1 | StdInChIKey_Ref = | StdInChIKey = YJSTYQGZKJHXLN-OLGWUGKESA-N }}Tosagestin ({{abbrlink|INN|International Nonproprietary Name}}, {{abbrlink|USAN|United States Adopted Name}}) (developmental code name ORG-30659), also known as 11-methylene-δ15-norethisterone or 17α-ethynyl-11-methylene-19-nor-δ15-testosterone, is a progestin of the 19-nortestosterone group which was under development by Organon in the United States and Europe as a hormonal contraceptive (in combination with ethinylestradiol) and for the treatment of menopausal symptoms but was never marketed.[2][3][4][5][6] See also
References1. ^{{cite book|author1=Martin Negwer|author2=Hans-Georg Scharnow|title=Organic-chemical drugs and their synonyms: (an international survey)|url=https://books.google.com/books?id=zmpqAAAAMAAJ|year=2001|publisher=Wiley-VCH|isbn=978-3-527-30247-5|page=2104}} 2. ^{{citation | author = World Health Organization | title = The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances | year = 2013 | page = 95 | url = http://apps.who.int/medicinedocs/collect/medicinedocs/pdf/s4895e/s4895e.pdf}} 3. ^{{citation | title = Tosagestin | author = AdisInsight | publisher = Springer | accessdate = 12 July 2016 | url = http://webcache.googleusercontent.com/search?q=cache:GunWHn-ThlcJ:adisinsight.springer.com/drugs/800012399+&cd=1&hl=en&ct=clnk&gl=us}} 4. ^{{cite journal | vauthors = Verhoeven CH, Krebbers SF, Wagenaars GN, Booy CJ, Groothuis GM, Olinga P, Vos RM | title = In vitro and in vivo metabolism of the progestagen Org 30659 in several species | journal = Drug Metab. Dispos. | volume = 26 | issue = 11 | pages = 1102–12 | year = 1998 | pmid = 9806953 | doi = | url = http://dmd.aspetjournals.org/content/26/11/1102.long}} 5. ^{{cite journal|last1=de Visser|first1=S.J.|last2=Uchida|first2=N.|last3=van Vliet-Daskalopoulou|first3=E.|last4=Fukazawa|first4=I.|last5=van Doorn|first5=M.B.A.|last6=van den Heuvel|first6=M.W.|last7=Machielsen|first7=C.S.M.|last8=Uchida|first8=E.|last9=Cohen|first9=A.F.|title=Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org 30659 and EE)|journal=Contraception|volume=68|issue=3|year=2003|pages=195–202|issn=0010-7824|doi=10.1016/S0010-7824(03)00140-9|pmid=14561540}} 6. ^{{cite journal|last1=Obruca|first1=Andreas|last2=Korver|first2=Tjeerd|last3=Huber|first3=Johannes|last4=Killick|first4=Stephen R|last5=Landgren|first5=Britt-Marie|last6=Struijs|first6=Martin J|title=Ovarian function during and after treatment with the new progestagen Org 30659|journal=Fertility and Sterility|volume=76|issue=1|year=2001|pages=108–115|issn=0015-0282|doi=10.1016/S0015-0282(01)01824-6|pmid=11438328}} External links
8 : Abandoned drugs|Alcohols|Alkynes|Dienes|Estranes|Hormonal contraception|Ketones|Progestogens |
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