| 词条 | Toxoplasma lactate dehydrogenase 1 regulatory UTR |
| 释义 |
| Name = LDH1 5'UTR | image = RF02697.svg | width = | caption = Predicted secondary structure and sequence conservation of LDH1 5'UTR | Symbol = | AltSymbols = | Rfam = RF02697 | miRBase = | miRBase_family = | RNA_type = | Tax_domain = Bacteria | GO = {{GO|0045182}} | SO = {{SO|0005836}},{{SO|0000204}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} In Toxoplasma gondii the translational repression of lactate dehydrogenase 1 (LDH1) was discovered to be mediated through its 5'UTR. A small nucleotide regulatory RNA hairpin was shown to be essential for the repression. It is possible that this hairpin may act as the nucleation site for the binding of an trans-acting factor(s) that allow for the translational repression.[1] References1. ^{{Cite journal|last=Holmes|first=Michael|last2=Itaas|first2=Vaunell|last3=Ananvoranich|first3=Sirinart|date=2014-11-01|title=Sustained translational repression of lactate dehydrogenase 1 in Toxoplasma gondii bradyzoites is conferred by a small regulatory RNA hairpin|journal=The FEBS Journal|volume=281|issue=22|pages=5077–5091|doi=10.1111/febs.13048|issn=1742-4658|pmid=25223457}} {{molecular-cell-biology-stub}} 3 : RNA|Non-coding RNA|Cis-regulatory RNA elements |
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