词条 | TRNP1 |
释义 |
FunctionTrnp1 binds to DNA with high affinity.[1] Its direct molecular function is unknown, it has no known molecular motif and therefore may represent a new class of molecules.[1] Trnp1 has a very strong effect on cellular proliferation, Trnp1 dramatically increases the proliferation rate in vitro an in vivo.[1] In addition to its stem cell function during brain development, there are data suggesting that Trnp1 might play a crucial role in cancer cells - Trnp1 has been described in gene expression analysis in cancer types.[4] the very strong proliferation capacity may be responsible for its oncogenic potential. Specifically, Trnp1 (together with other factors) serves as a biomarker for specific colon cancer subtypes.[4][5] References1. ^1 2 3 4 5 {{cite journal | vauthors = Stahl R, Walcher T, De Juan Romero C, Pilz GA, Cappello S, Irmler M, Sanz-Aquela JM, Beckers J, Blum R, Borrell V, Götz M | title = Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate | language = English | journal = Cell | volume = 153 | issue = 3 | pages = 535–49 | date = April 2013 | pmid = 23622239 | doi = 10.1016/j.cell.2013.03.027 | url = http://www.cell.com/cell/abstract/S0092-8674(13)00349-8 }} {{Protein-stub}}2. ^{{cite journal | vauthors = Fernández V, Llinares-Benadero C, Borrell V | title = Cerebral cortex expansion and folding: what have we learned? | journal = The EMBO Journal | volume = 35 | issue = 10 | pages = 1021–44 | date = May 2016 | pmid = 27056680 | pmc = 4868950 | doi = 10.15252/embj.201593701 | url = http://emboj.embopress.org/content/early/2016/04/07/embj.201593701 }} 3. ^{{cite journal | vauthors = Martínez-Martínez MÁ, De Juan Romero C, Fernández V, Cárdenas A, Götz M, Borrell V | title = A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels | journal = Nature Communications | volume = 7 | pages = 11812 | date = June 2016 | pmid = 27264089 | pmc = 4897765 | doi = 10.1038/ncomms11812 }} 4. ^1 {{cite journal | vauthors = Kanth P, Bronner MP, Boucher KM, Burt RW, Neklason DW, Hagedorn CH, Delker DA | title = Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype | journal = Cancer Prevention Research | volume = 9 | issue = 6 | pages = 456–65 | date = June 2016 | pmid = 27026680 | pmc = 4941619 | doi = 10.1158/1940-6207.CAPR-15-0363 }} 5. ^{{cite patent |country= US |number= 20190032147 | url = https://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=2019032147A1&KC=A1&FT=D&ND=3&date=20190131&DB=&locale=en_EP |status= application |title= Methods and compositions for predicting a colon cancer subtype |pubdate= 31 January 2019 |gdate= |fdate= 24 January 2017 |pridate= |inventor= Delker D, Kanth P |assign1= University of Utah Research Foundation }} 1 : Human proteins |
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