| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Trypsin domain containing 1 is a protein that in humans is encoded by the TYSND1 gene. [1]FunctionThis gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. References 1. ^{{cite web| title = Entrez Gene: Trypsin domain containing 1| url = https://www.ncbi.nlm.nih.gov/gene/219743| accessdate = 2017-10-02}}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A |title=A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease |journal=Am. J. Hum. Genet. |volume=78 |issue=1 |pages=78–88 |year=2006 |pmid=16385451 |pmc=1380225 |doi=10.1086/498851 |url=}}
- {{cite journal |vauthors=Kurochkin IV, Mizuno Y, Konagaya A, Sakaki Y, Schönbach C, Okazaki Y |title=Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids |journal=EMBO J. |volume=26 |issue=3 |pages=835–45 |year=2007 |pmid=17255948 |pmc=1794383 |doi=10.1038/sj.emboj.7601525 |url=}}
- {{cite journal |vauthors=Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR |title=Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score |journal=Mol. Med. |volume=16 |issue=7-8 |pages=247–53 |year=2010 |pmid=20379614 |pmc=2896464 |doi=10.2119/molmed.2009.00159 |url=}}
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