| 词条 | Ubrogepant |
| 释义 |
| IUPAC_name = (6S)-N-[(3S,5S,6R)-6-Methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3-piperidinyl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide | image = Ubrogepant.svg | alt = | caption = | pronounce = | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = | pregnancy_category= | routes_of_administration = | legal_AU = | legal_AU_comment = | legal_BR = | legal_BR_comment = | legal_CA = | legal_DE = | legal_NZ = | legal_UK = | legal_US = | legal_UN = | legal_status = Investigational | bioavailability = | protein_bound = | metabolism = | metabolites = | onset = | elimination_half-life = | duration_of_action= | excretion = | CAS_number = 1374248-77-7 | class = | ATCvet = | ATC_prefix = none | ATC_suffix = | PubChem = 68748835 | DrugBank = | ChemSpiderID = 28536135 | ChEMBL = 2364638 | UNII = AD0O8X2QJR | KEGG = D10673 | synonyms = MK-1602 | chemical_formula = | C=29 | H=26 | F=3 | N=5 | O=3 | smiles = C[C@@H]1[C@@H](C[C@@H](C(=O)N1CC(F)(F)F)NC(=O)c2cc3c(nc2)C[C@@]4(C3)c5cccnc5NC4=O)c6ccccc6 | StdInChI=1S/C29H26F3N5O3/c1-16-20(17-6-3-2-4-7-17)11-22(26(39)37(16)15-29(30,31)32)35-25(38)19-10-18-12-28(13-23(18)34-14-19)21-8-5-9-33-24(21)36-27(28)40/h2-10,14,16,20,22H,11-13,15H2,1H3,(H,35,38)(H,33,36,40)/t16-,20-,22+,28+/m1/s1 | StdInChIKey = DDOOFTLHJSMHLN-ZQHRPCGSSA-N }}Ubrogepant is an experimental drug for the treatment of migraine. It is a small-molecule calcitonin gene-related peptide receptor antagonist.[1][2] References1. ^{{cite journal | last1 = Tfelt-Hansen | first1 = P | last2 = Olesen | first2 = J | title = Possible Site of Action of CGRP Antagonists in Migraine | journal = Cephalalgia: An International Journal of Headache | date = April 2011 | volume = 31 | issue = 6 | pages = 748–50 | doi = 10.1177/0333102411398403 | pmid = 21383046}} {{Signaling peptide/protein receptor modulators}}{{analgesic-stub}}2. ^{{cite journal | last1 = Spreitzer | first1 = H | title = Neue Wirkstoffe: Ubrogepant | journal = Österreichische Apotheker-Zeitung | date = 22 May 2018 | issue = 11/2018 | language = German}} 2 : Antimigraine drugs|Carboxamides |
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