| 词条 | Uridine triacetate |
| 释义 |
| drug_name = | IUPAC_name = 2',3',5'-Tri-O-acetyluridine | image = Uridine triacetate structure.svg | width = 150 | alt = | caption = | pronounce = | tradename = Vistogard, Xuriden | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_AU_comment = | legal_CA = | legal_DE = | legal_NZ = | legal_UK = | legal_US = Rx-only | legal_UN = | legal_status = | routes_of_administration = Oral granules | bioavailability = | protein_bound = | metabolism = Pyrimidine catabolic pathway | metabolites = | onset = Tmax = 2–3 hours | elimination_half-life = 2–2.5 hours | duration_of_action = | excretion = Renal | CAS_number = 4105-38-8 | ATCvet = | ATC_prefix = A16 | ATC_suffix = AX13 | PubChem = 20058 | ChemSpiderID = 18897 | DrugBank = DB09144 | KEGG = D09985 | UNII = 2WP61F175M | chemical_formula = | C=15 | H=18 | N=2 | O=9 | molecular_weight = | SMILES = CC(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n2ccc(=O)[nH]c2=O)OC(=O)C)OC(=O)C | StdInChI=1S/C15H18N2O9/c1-7(18)23-6-10-12(24-8(2)19)13(25-9(3)20)14(26-10)17-5-4-11(21)16-15(17)22/h4-5,10,12-14H,6H2,1-3H3,(H,16,21,22)/t10-,12-,13-,14-/m1/s1 | StdInChIKey = AUFUWRKPQLGTGF-FMKGYKFTSA-N }} Uridine triacetate (INN),[1] formerly known as vistonuridine, is an orally active tri-acetylated prodrug of uridine[2] used:
Uridine triacetate was developed, manufactured and distributed by Wellstat Therapeutics. Also, It was granted breakthrough therapy designation by FDA in 2015. References1. ^{{cite web|title=International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 65|url=http://www.who.int/medicines/publications/druginformation/innlists/RL65.pdf|publisher=World Health Organization|accessdate=12 March 2017|page=92}} 2. ^{{cite web|title=Uridine triacetate — DrugBank Page|url=https://www.drugbank.ca/drugs/DB09144|date=12 March 2017}} 3. ^{{cite web|title=Xuriden (uridine triacetate) Oral Granules. Full Prescribing Information|url=http://www.xuriden.com/FPI.pdf|publisher=Wellstat Therapeutics Corporation. Gaithersburg, MD 20878|accessdate=12 March 2017}} 4. ^{{cite web|title=Vistogard (uridine triacetate) Oral Granules. Full Prescribing Information|url=https://www.vistogard.com/Vistogard/media/Main-Media/final-labeling-text-vistogard.pdf|publisher=Wellstat Therapeutics Corporation. Gaithersburg, MD 20878|accessdate=12 March 2017}} 5. ^{{cite news|title=BTG Announces FDA Approval of Vistogard® (Uridine Triacetate) as Antidote to Overdose and Early Onset, Severe, or Life-Threatening Toxicities from Chemotherapy Drugs 5-Fluorouracil (5-FU) or Capecitabine|url=https://www.btgplc.com/media/press-releases/btg-announces-fda-approval-of-vistogard/|accessdate=12 March 2017|publisher=BTG International Ltd.|date=11 December 2015}} 6. ^{{cite web|title=Approved Drugs — Uridine Triacetate|url=https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm476930.htm|publisher=U.S. Food and Drug Administration|accessdate=12 March 2017|language=en}} External links
3 : Antidotes|Acetate esters|Prodrugs |
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