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词条 Velvet complex
释义

  1. References

Velvet complex is a group of proteins found in fungi and especially molds that are important in reproduction and production of secondary metabolites including penicillin. The core members of the complex include VeA, LaeA (loss of aflR-expression A), and VelB.[1][2][3] Other proteins including VelC and VosA sometimes function in the complex.[1] The proteins were first characaterized in Aspergillus nidulans.[2]

Some proteins in the complex are light-sensitive, including the founding member, VeA (Velvet A), which was first described in 1965.[2]

Four of these proteins, VeA, VelB, VelC, and VosA, have an approximately 200 amino acid domain called the velvet domain.[2]

References

1. ^1 {{cite journal|last1=Martín|first1=JF|title=Key role of LaeA and velvet complex proteins on expression of β-lactam and PR-toxin genes in Penicillium chrysogenum: cross-talk regulation of secondary metabolite pathways.|journal=Journal of Industrial Microbiology & Biotechnology|date=May 2017|volume=44|issue=4–5|pages=525–535|doi=10.1007/s10295-016-1830-y|pmid=27565675}}
2. ^1 2 3 4 {{cite journal|last1=Gerke|first1=J|last2=Braus|first2=GH|title=Manipulation of fungal development as source of novel secondary metabolites for biotechnology.|journal=Applied Microbiology and Biotechnology|date=October 2014|volume=98|issue=20|pages=8443–55|doi=10.1007/s00253-014-5997-8|pmid=25142695|pmc=4192562}}
3. ^{{cite journal|last1=Amare|first1=MG|last2=Keller|first2=NP|title=Molecular mechanisms of Aspergillus flavus secondary metabolism and development.|journal=Fungal Genetics and Biology|date=May 2014|volume=66|pages=11–8|doi=10.1016/j.fgb.2014.02.008|pmid=24613992}}
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1 : Fungal proteins
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