| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Villin 1 is a protein that in humans is encoded by the VIL1 gene. [1]FunctionThis gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]. References 1. ^{{cite web| title = Entrez Gene: Villin 1| url = https://www.ncbi.nlm.nih.gov/gene/7429| accessdate = 2018-09-27}}
Further reading {{refbegin | 30em}}- {{cite journal |vauthors=Zhai L, Zhao P, Panebra A, Guerrerio AL, Khurana S |title=Tyrosine phosphorylation of villin regulates the organization of the actin cytoskeleton |journal=J. Biol. Chem. |volume=276 |issue=39 |pages=36163–7 |date=September 2001 |pmid=11500485 |doi=10.1074/jbc.C100418200 |url=}}
- {{cite journal |vauthors=Kumar N, Tomar A, Parrill AL, Khurana S |title=Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin |journal=J. Biol. Chem. |volume=279 |issue=43 |pages=45036–46 |date=October 2004 |pmid=15272027 |doi=10.1074/jbc.M405424200 |url=}}
- {{cite journal |vauthors=Tomar A, Wang Y, Kumar N, George S, Ceacareanu B, Hassid A, Chapman KE, Aryal AM, Waters CM, Khurana S |title=Regulation of cell motility by tyrosine phosphorylated villin |journal=Mol. Biol. Cell |volume=15 |issue=11 |pages=4807–17 |date=November 2004 |pmid=15342783 |pmc=524729 |doi=10.1091/mbc.e04-05-0431 |url=}}
- {{cite journal |vauthors=Rieder G, Tessier AJ, Qiao XT, Madison B, Gumucio DL, Merchant JL |title=Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin |journal=J. Biol. Chem. |volume=280 |issue=6 |pages=4906–12 |date=February 2005 |pmid=15576363 |doi=10.1074/jbc.M413399200 |url=}}
- {{cite journal |vauthors=Revenu C, Courtois M, Michelot A, Sykes C, Louvard D, Robine S |title=Villin severing activity enhances actin-based motility in vivo |journal=Mol. Biol. Cell |volume=18 |issue=3 |pages=827–38 |date=March 2007 |pmid=17182858 |pmc=1805090 |doi=10.1091/mbc.e06-05-0423 |url=}}
- {{cite journal |vauthors=Khurana S, Tomar A, George SP, Wang Y, Siddiqui MR, Guo H, Tigyi G, Mathew S |title=Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia |journal=Exp. Cell Res. |volume=314 |issue=3 |pages=530–42 |date=February 2008 |pmid=18054784 |pmc=2680351 |doi=10.1016/j.yexcr.2007.10.028 |url=}}
- {{cite journal |vauthors=Khurana S, George SP |title=Regulation of cell structure and function by actin-binding proteins: villin's perspective |journal=FEBS Lett. |volume=582 |issue=14 |pages=2128–39 |date=June 2008 |pmid=18307996 |pmc=2680319 |doi=10.1016/j.febslet.2008.02.040 |url=}}
- {{cite journal |vauthors=Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, Haraguchi T, Mizutani T, Fujishiro M, Shimomura R, Oka M, Ichinose M, Tsutsumi Y, Omata M, Iba H |title=Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells |journal=Exp. Cell Res. |volume=315 |issue=10 |pages=1779–89 |date=June 2009 |pmid=19371634 |doi=10.1016/j.yexcr.2009.01.006 |url=}}
- {{cite journal |vauthors=Nakamura E, Iwakawa M, Furuta R, Ohno T, Satoh T, Nakawatari M, Ishikawa K, Imadome K, Michikawa Y, Tamaki T, Kato S, Kitagawa T, Imai T |title=Villin1, a novel diagnostic marker for cervical adenocarcinoma |journal=Cancer Biol. Ther. |volume=8 |issue=12 |pages=1146–53 |date=June 2009 |pmid=19377296 |doi= |url=}}
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