| 词条 | Vonoprazan |
| 释义 |
| IUPAC_name = 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine | image = Vonoprazan structure.svg | alt = Skeletal formula of a vonoprazan molecule | pronounce = | tradename = Takecab | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = | pregnancy_category= | routes_of_administration = | legal_AU = | legal_AU_comment = | legal_CA = | legal_DE = | legal_NZ = | legal_UK = | legal_US = | legal_UN = | legal_status = | bioavailability = Unknown | protein_bound = 80% | metabolism = Hepatic, by cytochrome P450 (3A4, 2B6, 2C19, 2D6) | metabolites = | onset = | elimination_half-life = 7.7 h | duration_of_action = > 24 h | excretion = Renal | CAS_number = 881681-00-1 | CAS_supplemental = {{CAS|1260141-27-2}} (fumarate) | ATCvet = | ATC_prefix = None | ATC_suffix = | PubChem = | DrugBank = | ChemSpiderID = 13112797 | KEGG = D10466 | C=17|H=16|F=1|N=3|O=2|S=1 | molecular_weight = | SMILES = Fc1ccccc1-c2cc(CNC)cn2S(=O)(=O)c3cccnc3 | StdInChI = InChI=1S/C17H16FN3O2S/c1-19-10-13-9-17(15-6-2-3-7-16(15)18)21(12-13)24(22,23)14-5-4-8-20-11-14/h2-9,11-12,19H,10H2,1H3 | StdInChIKey = BFDBKMOZYNOTPK-UHFFFAOYSA-N }}Vonoprazan fumarate is a first-in-class potassium-competitive acid blocker. It was approved in the Japanese market in February 2015.[1] Vonoprazan can be used for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori.[2] References1. ^{{cite journal |vauthors=Garnock-Jones KP |title=Vonoprazan: first global approval |journal=Drugs |volume=75 |issue=4 |pages=439–43 |year=2015 |pmid=25744862 |doi=10.1007/s40265-015-0368-z}} {{Drugs for peptic ulcer and GORD}}{{Gastrointestinal-drug-stub}}2. ^{{cite journal |vauthors=Echizen H |title=The First-in-Class Potassium-Competitive Acid Blocker, Vonoprazan Fumarate: Pharmacokinetic and Pharmacodynamic Considerations |journal=Clin Pharmacokinet |volume=55 |issue=4 |pages=409–18 |year=2016 |pmid=26369775 |doi=10.1007/s40262-015-0326-7}} 2 : Drugs acting on the gastrointestinal system and metabolism|Proton pump inhibitors |
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