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词条 Weaver Syndrome
释义

  1. References

Bovine progressive degenerative myeloencephalopathy (BPDME), also known as weaver syndrome, is a genetic disorder of cattle, characterized by hindlimb weakness and ataxia. It has been observed in male and female Brown Swiss cattle. It is known as 'weaver syndrome' because of the animals' 'weaving' gait while walking.[1] BPDME is a genetic autosomal recessive disorder.[2]

The signs of BPDME are first noticed in cattle aged 5–8 months,[3] and include a weaving gait, along with weakness and lack of voluntary coordination of the muscles of the hind limbs (known as ataxia).[2] Signs progressively worsen, and by 18–36 months of age, the animal is unable to rise.[4] Affected animals are euthanized for welfare reasons.[2]

References

1. ^{{citation |authors=John D. Baird, Ulla M. Sarmiento, Parvathi K. Basrur |title=Bovine Progressive Degenerative Myeloencephalopathy (Weaver Syndrome) in Brown Swiss Cattle in Canada: A Literature Review and Case Report |journal=Canadian Veterinary Journal |year=1988 |volume=29 |number=4 |pages=370–377 |PMID=17423028 |PMC=1680902 }}
2. ^{{cite journal |last1=Kunz |first1=E |last2=Rothammer |first2=S |last3=Pausch |first3=H |last4=Schwarzenbacher |first4=H |last5=Seefried |first5=FR |last6=Matiasek |first6=K |last7=Seichter |first7=D |last8=Russ |first8=I |last9=Fries |first9=R |last10=Medugorac |first10=I |title=Confirmation of a non-synonymous SNP in PNPLA8 as a candidate causal mutation for Weaver syndrome in Brown Swiss cattle |journal=Genetics, Selection, Evolution|date=18 March 2016 |volume=48 |pages=21 |doi=10.1186/s12711-016-0201-5 |pmid=26992691 |pmc=4797220}}
3. ^{{cite book |last1=Lorenz |first1=Michael D. |last2=Coates |first2=Joan R. |last3=Kent |first3=Marc |title=Handbook of Veterinary Neurology |date=2011 |publisher=Elsevier/Saunders |location=St. Louis, Missouri |isbn=978-1-4377-0651-2 |page=179 |edition=5th}}
4. ^{{cite book |editor1-last=Divers |editor1-first=Thomas J. |editor2-last=Peek |editor2-first=Simon F. |title=Rebhun's Diseases of Dairy cattle |date=2008 |publisher=Saunders Elsevier |location=St. Louis, Missouri |isbn=978-1-4160-3137-6 |edition=2nd |chapter=Degenerative myeloencephalopathy of Brown Swiss Cattle}}

2 : Bovine diseases|Genetic animal diseases

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