Wheeler Creek may refer to:

• Wheeler Creek (Eel River), a stream in Indiana
• Wheeler Creek (Grindstone Creek), a stream in Missouri

• Hex (Marvel Comics)
• Hex numeral system
• Hexobarbitone
• Hexobion
• Hexocycnidolon
• Hexoloy
• Hexonix
• Hexon protein
• Hexonychia
• Hexonychia stellatum
• Hexophene
• Hexopia
• Hexoplon
• Hexoplon affine
• Hexoplon albipenne
• Hexoplon annulatum
• Hexoplon anthracinum
• Hexoplon armatum
• Hexoplon bellulum
• Hexoplon bucki
• Hexoplon calligrammum
• Hexoplon carissimum
• Hexoplon cearense
• Hexoplon ctenostomoides
• Hexoplon eximium