Wikoff is a surname. Notable people with the surname include:

• Allen T. Wikoff (1825-1902), U.S. Republican politician
• Charles A. Wikoff (1837-1898), the most senior ranking American Army officer killed in the Spanish–American War
• Henry Wikoff (1811–1884), American traveler and writer
• Lester B. Wikoff (1893–1978), U.S. Colonel and Superintendent of Wentworth Military Academy

• Bertha Berry (born Bertha Wikoff)(1876–1954) nurse and hospital founder

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