Worst Friends may refer to:

• Worst Friends (2009 film), a 2009 Korean film
• Worst Friends (2014 film), a 2014 American film

• PanAmSat Corporation
• Panam Sports
• Pan Am World Airways
• Pan Am Worldport
• Panamá City, Panamá
• Panamá City Temple
• Panamá, Goiás
• Panamá hat
• Panamá Temple
• Panamá Viejo F.C.
• Pan-and-scan
• Pan and Scan
• Panang
• Panangkaran
• Pan-Anglican Congress
• Pananmal Punjabi
• Pana-on
• Panaon Island
• Pana, Ontario
• Panapakkam
• Pana Pana
• Panapet
• Panaqolus maccus
• Panaque
• Panaque cochliodon