1. Function

2. References

3. Further reading

Zinc finger and SCAN domain containing 4 is a protein that in humans is encoded by the ZSCAN4 gene.

Function

The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).

References

Further reading

• {{cite journal |vauthors=Lee K, Gollahon LS |title=Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status |journal=Cancer Biol. Ther. |volume=15 |issue=8 |pages=1094–105 |year=2014 |pmid=24840609 |pmc=4119077 |doi=10.4161/cbt.29220 |url=}}
• {{cite journal |vauthors=Lee K, Gollahon LS |title=ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity |journal=Biochem. Biophys. Res. Commun. |volume=466 |issue=4 |pages=644–9 |year=2015 |pmid=26403970 |doi=10.1016/j.bbrc.2015.09.107 |url=}}
• {{cite journal |vauthors=Ishiguro KI, Nakatake Y, Chikazawa-Nohtomi N, Kimura H, Akiyama T, Oda M, Ko SB, Ko MS |title=Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos |journal=In Vitro Cell. Dev. Biol. Anim. |volume=53 |issue=2 |pages=179–190 |year=2017 |pmid=27699651 |pmc=5311086 |doi=10.1007/s11626-016-0097-y |url=}}

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