1. Production and use

2. References

Production and use

In one example of producing an anti-idiotypic vaccine, antibodies that bind tumor-associated antigens (TAA) are isolated and injected into mice. To the murine immune system, the TAA antibodies are antigens and cause an immunogenic reaction producing murine antibodies that can bind to the "TAA idiotype" and is said to be "anti-idiotypic". The resulting murine antibodies are harvested and used to vaccinate other mice. The resulting antibodies in the second set of mice have a three-dimensional binding site that mimics the original antibodies that bind tumor-associated antigens. These antibodies are combined with an adjuvant and given as a vaccine. The murine immune system essentially "amplifies" a small mass of TAA antibodies into a much larger mass used to vaccinate humans. Because the antibody produced using the "anti-idiotypic" process closely resembles the original epitope of the antigen, these antibodies can be used to induce immune responses from cellular to antibody-antigen for a given antigen, e. g., TAA, when administered as a vaccine to a human. They are mainly used for high risk cancer patients.

References

• Ansel's Pharmaceutical Dosage Forms and Drug Delivery System (Page 513) ({{ISBN|0-7817-4612-4}})

• Boeing C-135B
• Boeing C-135B-BN Stratolifter
• Boeing C-17A Globemaster III Lot VIII
• Boeing C-17A Lot XII Globemaster III
• Boeing C-17 Globemaster III in Australian service
• Boeing C-75 Stratoliner
• Boeing C-97C-35-BO
• Boeing C-97C-35-BO Stratofreighter
• Boeing C-97C Stratofreighter
• Boeing C-97G Stratofreighter
• Boeing C-98 Clipper
• Boeing Calc
• Boeing-Canada Canso A
• Boeing-Canada PB2B-1
• Boeing-Canada PB2B-1 Catalina IVB
• Boeing-Canada PB2B-2
• Boeing-Canada PBY-5A
• Boeing CC-177 Globemaster
• Boeing CEM-138 Pave Cricket
• Boeing CGM-121 Seek Spinner
• Boeing CH-147 Chinook
• Boeing Charleston Factory
• Boeing Chinook HC.1
• Boeing Chinook HC.2
• Boeing CIM-10B Bomarc