“Anti-sp100 antibodies”的意思、由来-开放百科全书

词条

Anti-sp100 antibodies

释义

Immunodominant regions of sp100
References

Anti-sp100 antibodies are found in association with primary biliary cirrhosis.^[1] The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis. 20-30% of patients suffering from primary biliary cirrhosis have sp100 Abs. The sera of these patients exhibit a characteristic "nuclear dots" pattern in indirect immunofluorescence (IIF) on Hep-2 cells.

Immunodominant regions of sp100

Antigenic region 1 - positions 296-311 - Sequence (I K K E K P F S N S K V E C Q A)
Antigenic region 2 - positions 332-351 - Sequence (E G S T D V D E P L E V F I S A P R S E)

(Bolded areas represent the core epitope.)^[2]

References

1. ^{{cite journal |vauthors=Szostecki C, Guldner HH, Netter HJ, Will H | title = Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis | journal = J. Immunol. | volume = 145 | issue = 12 | pages = 4338–47 | year = 1990 | pmid = 2258622 | doi = }}
2. ^{{cite journal |vauthors=Blüthner M, Schäfer C, Schneider C, Bautz FA | title = Identification of major linear epitopes on the sp100 nuclear PBC autoantigen by the gene-fragment phage-display technology | journal = Autoimmunity | volume = 29 | issue = 1 | pages = 33–42 | year = 1999 | pmid = 10052683 | doi =10.3109/08916939908995970 }}

2 : Autoantibodies|PBC autoantibodies

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