| 词条 | Anti-thrombin antibodies |
| 释义 |
|Autoantigen = Thrombin |OneIsoform = Yes |OneIsoformSpecialName = coagulation- factor II |OneGene = F2 |OneOrgan = Cardiovascular |OneTissue = serum |OneCell = blood platelets |OneAlso = serum protein inhibitor |OneDisease = Systemic lupus erythematosus |OneIgClass = |OneIgGSubclass = |OneHLA1 = |OneHLA2 = |OneHLA3 = |OneAssociatedGene = |OneTCellRestr = |OneTrigger = }} Anti-thrombin antibodies are autoantibodies directed against thrombin that may constitute a fraction of lupus anticoagulant and are seen an increased levels in systemic lupus erythematosus. In mammals, there is normally occurring anti-thrombin activity (antithrombin III), which can be distinguished from autoimmune anti-thrombin. Anti-thrombin antibodies can react with both types of thrombin in the antithrombin-thrombin complex.[1] Antibodies (IgG) against thrombin can strongly inhibit its activity.[2] Inhibitory anti-thrombin antibodies can be divided into 2 groups, those that inhibit coagulation activity and those the inhibit coagulation and amidase activity.[3] Autoimmune anti-thrombin was also found to inhibit the binding of antithrombin III to thrombin.[4] Such activities are more often found with primary biliary cirrhosis.[4][5] Multiple studies have shown, however, that despite autoimmune anti-thrombin thrombin inhibitory activity, these antibodies correlate with thrombotic events, so that they may also perturb the regulation of coagalatory factors. Other than antibodies to thrombin, antibodies to vascular heparin sulfate appear to interfere with antithrombin-thrombin interaction.[6] References1. ^{{cite journal |vauthors=McDuffie FC, Peterson JM, Clark G, Mann KG | title = Antigenic changes produced by complex formation between thrombin and antithrombin-III | journal = J. Immunol. | volume = 127 | issue = 1 | pages = 239–44 | year = 1981 | pmid = 6787123 | doi = }} {{Autoantibodies}}2. ^{{cite journal |vauthors=Scully MF, Ellis V, Kakkar VV, Savidge GF, Williams YF, Sterndale H | title = An acquired coagulation inhibitor to factor II | journal = Br. J. Haematol. | volume = 50 | issue = 4 | pages = 655–64 | year = 1982 | pmid = 7066212 | doi =10.1111/j.1365-2141.1982.tb01966.x }} 3. ^{{cite journal |vauthors=Dawes J, James K, Micklem LR, Pepper DS, Prowse CV | title = Monoclonal antibodies directed against human alpha-thrombin and the thrombin-antithrombin III complex | journal = Thromb. Res. | volume = 36 | issue = 5 | pages = 397–409 | year = 1984 | pmid = 6523447 | doi =10.1016/0049-3848(84)90296-2 }} 4. ^1 {{cite journal |vauthors=Barthels M, Heimburger N | title = Acquired thrombin inhibitor in a patient with liver cirrhosis | journal = Haemostasis | volume = 15 | issue = 6 | pages = 395–401 | year = 1985 | pmid = 4076847 | doi = 10.1159/000215179}} 5. ^{{cite journal |vauthors=Shojania AM, Meilleur G, Alvi AW | title = An autoantibody with potent antithrombin activity whose action could be inhibited by toluidine blue or methylene blue | journal = Am. J. Hematol. | volume = 24 | issue = 2 | pages = 207–14 | year = 1987 | pmid = 3812468 | doi =10.1002/ajh.2830240212 }} 6. ^{{cite journal |vauthors=Shibata S, Sasaki T, Harpel P, Fillit H | title = Autoantibodies to vascular heparan sulfate proteoglycan in systemic lupus erythematosus react with endothelial cells and inhibit the formation of thrombin-antithrombin III complexes | journal = Clin. Immunol. Immunopathol. | volume = 70 | issue = 2 | pages = 114–23 | year = 1994 | pmid = 8299226 | doi =10.1006/clin.1994.1018 }} 1 : Autoantibodies |
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