| 词条 | Antrafenine |
| 释义 |
| Watchedfields = changed | verifiedrevid = 437136259 | IUPAC_name = 2- | image = Antrafenine.svg | tradename = | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Oral | bioavailability = | metabolism = Hepatic | elimination_half-life = | excretion = Renal | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 55300-30-6 | ATC_prefix = none | ATC_suffix = | PubChem = 68723 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB01419 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 61973 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 21FS93Y6OE | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 345524 | C=30 | H=26 | F=6 | N=4 | O=2 | molecular_weight = 588.543 g/mol | smiles = FC(F)(F)c5ccc1c(nccc1Nc2ccccc2C(=O)OCCN4CCN(c3cc(ccc3)C(F)(F)F)CC4)c5 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C30H26F6N4O2/c31-29(32,33)20-4-3-5-22(18-20)40-14-12-39(13-15-40)16-17-42-28(41)24-6-1-2-7-25(24)38-26-10-11-37-27-19-21(30(34,35)36)8-9-23(26)27/h1-11,18-19H,12-17H2,(H,37,38) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = NWGGKKGAFZIVBJ-UHFFFAOYSA-N }} Antrafenine (Stakane) is a phenylpiperazine derivative drug invented in 1979.[1] It acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen,[2] but is not widely used as it has largely been replaced by newer drugs. See also
References1. ^Manoury PM, Dumas AP, Najer H, Branceni D, Prouteau M, Lefevre-Borg FM. Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. Journal of Medicinal Chemistry. 1979 May;22(5):554-9. {{Anti-inflammatory}}{{Analgesics}}{{Prostanoidergics}}{{Piperazines}}{{pharmacy-stub}}2. ^Leatham PA, Bird HA, Wright V, Seymour D, Gordon A. A double blind study of antrafenine, naproxen and placebo in osteoarthrosis. European Journal of Rheumatology and Inflammation. 1983;6(2):209-11. 4 : Piperazines|Trifluoromethyl compounds|Anthranilates|Quinolines |
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