“AP2M1”的意思、由来-开放百科全书

Function

This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.^[2]

Interactions

AP2M1 has been shown to interact with CTLA-4^[3]^[4] and Alpha-1B adrenergic receptor.^[5]

References

1. ^{{cite journal | vauthors = Druck T, Gu Y, Prabhala G, Cannizzaro LA, Park SH, Huebner K, Keen JH | title = Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP | journal = Genomics | volume = 30 | issue = 1 | pages = 94–7 | date = Nov 1995 | pmid = 8595912 | pmc = | doi = 10.1006/geno.1995.0016 }}
2. ^{{cite web | title = Entrez Gene: AP2M1 adaptor-related protein complex 2, mu 1 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1173| accessdate = }}
3. ^{{cite journal | vauthors = Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, Rowsell S, Stacey CL, Stanway JJ, Taylor IW, Abbott WM | title = Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28 | journal = The Biochemical Journal | volume = 359 | issue = Pt 2 | pages = 427–34 | date = Oct 2001 | pmid = 11583591 | pmc = 1222163 | doi = 10.1042/0264-6021:3590427 }}
4. ^{{cite journal | vauthors = Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB | title = Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression | journal = Journal of Immunology | volume = 159 | issue = 1 | pages = 144–51 | date = Jul 1997 | pmid = 9200449 }}
5. ^{{cite journal | vauthors = Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S | title = The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis | journal = The Journal of Biological Chemistry | volume = 278 | issue = 21 | pages = 19331–40 | date = May 2003 | pmid = 12644451 | doi = 10.1074/jbc.M302110200 }}

Further reading

{{cite journal | vauthors = Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS | title = Interaction of tyrosine-based sorting signals with clathrin-associated proteins | journal = Science | volume = 269 | issue = 5232 | pages = 1872–5 | date = Sep 1995 | pmid = 7569928 | doi = 10.1126/science.7569928 }}

{{cite journal | vauthors = Liu Q, Feng Y, Forgac M | title = Activity and in vitro reassembly of the coated vesicle (H+)-ATPase requires the 50-kDa subunit of the clathrin assembly complex AP-2 | journal = The Journal of Biological Chemistry | volume = 269 | issue = 50 | pages = 31592–7 | date = Dec 1994 | pmid = 7989329 | doi = }}

{{cite journal | vauthors = Pauloin A, Thurieau C | title = The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides | journal = The Biochemical Journal | volume = 296 ( Pt 2) | issue = 2 | pages = 409–15 | date = Dec 1993 | pmid = 8257432 | pmc = 1137711 | doi = }}

{{cite journal | vauthors = Chang MP, Mallet WG, Mostov KE, Brodsky FM | title = Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits | journal = The EMBO Journal | volume = 12 | issue = 5 | pages = 2169–80 | date = May 1993 | pmid = 8491205 | pmc = 413438 | doi = }}

{{cite journal | vauthors = Wang X, Kilimann MW | title = Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2 | journal = FEBS Letters | volume = 402 | issue = 1 | pages = 57–61 | date = Jan 1997 | pmid = 9013859 | doi = 10.1016/S0014-5793(96)01500-1 }}

{{cite journal | vauthors = Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB | title = Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression | journal = Journal of Immunology | volume = 159 | issue = 1 | pages = 144–51 | date = Jul 1997 | pmid = 9200449 | doi = }}

{{cite journal | vauthors = Zhang Y, Allison JP | title = Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 17 | pages = 9273–8 | date = Aug 1997 | pmid = 9256472 | pmc = 23153 | doi = 10.1073/pnas.94.17.9273 }}

{{cite journal | vauthors = Ohno H, Aguilar RC, Fournier MC, Hennecke S, Cosson P, Bonifacino JS | title = Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family | journal = Virology | volume = 238 | issue = 2 | pages = 305–15 | date = Nov 1997 | pmid = 9400603 | doi = 10.1006/viro.1997.8839 }}

{{cite journal | vauthors = Santini F, Marks MS, Keen JH | title = Endocytic clathrin-coated pit formation is independent of receptor internalization signal levels | journal = Molecular Biology of the Cell | volume = 9 | issue = 5 | pages = 1177–94 | date = May 1998 | pmid = 9571248 | pmc = 25339 | doi = 10.1091/mbc.9.5.1177 }}

{{cite journal | vauthors = Owen DJ, Evans PR | title = A structural explanation for the recognition of tyrosine-based endocytotic signals | journal = Science | volume = 282 | issue = 5392 | pages = 1327–32 | date = Nov 1998 | pmid = 9812899 | doi = 10.1126/science.282.5392.1327 }}

{{cite journal | vauthors = Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R | title = Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins | journal = Journal of Virology | volume = 73 | issue = 2 | pages = 1350–61 | date = Feb 1999 | pmid = 9882340 | pmc = 103959 | doi = }}

{{cite journal | vauthors = Teuchert M, Berghöfer S, Klenk HD, Garten W | title = Recycling of furin from the plasma membrane. Functional importance of the cytoplasmic tail sorting signals and interaction with the AP-2 adaptor medium chain subunit | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36781–9 | date = Dec 1999 | pmid = 10593987 | doi = 10.1074/jbc.274.51.36781 }}

{{cite journal | vauthors = Umeda A, Meyerholz A, Ungewickell E | title = Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation | journal = European Journal of Cell Biology | volume = 79 | issue = 5 | pages = 336–42 | date = May 2000 | pmid = 10887964 | doi = 10.1078/S0171-9335(04)70037-0 }}

{{cite journal | vauthors = Jullien-Flores V, Mahé Y, Mirey G, Leprince C, Meunier-Bisceuil B, Sorkin A, Camonis JH | title = RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis | journal = Journal of Cell Science | volume = 113 ( Pt 16) | issue = 16 | pages = 2837–44 | date = Aug 2000 | pmid = 10910768 | doi = }}

{{cite journal | vauthors = Wyss S, Berlioz-Torrent C, Boge M, Blot G, Höning S, Benarous R, Thali M | title = The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter] | journal = Journal of Virology | volume = 75 | issue = 6 | pages = 2982–92 | date = Mar 2001 | pmid = 11222723 | pmc = 115924 | doi = 10.1128/JVI.75.6.2982-2992.2001 }}

{{cite journal | vauthors = Morris SM, Cooper JA | title = Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2 | journal = Traffic | volume = 2 | issue = 2 | pages = 111–23 | date = Feb 2001 | pmid = 11247302 | doi = 10.1034/j.1600-0854.2001.020206.x }}

{{cite journal | vauthors = Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, Rowsell S, Stacey CL, Stanway JJ, Taylor IW, Abbott WM | title = Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28 | journal = The Biochemical Journal | volume = 359 | issue = Pt 2 | pages = 427–34 | date = Oct 2001 | pmid = 11583591 | pmc = 1222163 | doi = 10.1042/0264-6021:3590427 }}

{{cite journal | vauthors = Friocourt G, Chafey P, Billuart P, Koulakoff A, Vinet MC, Schaar BT, McConnell SK, Francis F, Chelly J | title = Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system | journal = Molecular and Cellular Neurosciences | volume = 18 | issue = 3 | pages = 307–19 | date = Sep 2001 | pmid = 11591131 | doi = 10.1006/mcne.2001.1022 }}

Function

Interactions

References

Further reading

External links