| 词条 | Aphthovirus internal ribosome entry site (IRES) |
| 释义 |
| Name = Aphthovirus internal ribosome entry site (IRES) | image = RF00210.jpg | width = | caption = Predicted secondary structure and sequence conservation of IRES_Aptho | Symbol = IRES_Aptho | AltSymbols = Aptho_IRES | Rfam = RF00210 | miRBase = | miRBase_family = | RNA_type = Cis-reg; IRES | Tax_domain = Viruses | GO = {{GO|0043022}} | SO = {{SO|0000243}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} This family represents the internal ribosome entry site (IRES) of the Picornaviruses.[1] IRES elements allow cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor eIF4F.[2] References1. ^{{cite journal|last=Fernandez-Miragall|first=O|author2=Martinez-Salas E|date=|year=2003|title=Structural organization of a viral IRES depends on the integrity of the GNRA motif|url=https://digital.csic.es/bitstream/10261/8288/1/OFernandez-Miragall_RNA_1333.pdf|journal=RNA|volume=9|issue=11|pages=1333-1344|doi=10.1261/rna.5950603|pmc=1287055|pmid=14561883|via=}} 2. ^{{cite journal|last=Kolupaeva|first=VG|author2=Pestova TV|author3=Hellen CU|date=|year=2000|title=Ribosomal binding to the internal ribosomal entry site of classical swine fever virus|url=|journal=RNA|volume=6|issue=12|pages=1791-1807|doi=10.1017/S1355838200000662|pmc=1370049|pmid=11142379|via=}} External links
3 : Cis-regulatory RNA elements|Internal ribosome entry site|Aphthoviruses |
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