| 词条 | Aquaretic |
| 释义 |
An aquaretic is a class of drug that is used to promote aquaresis, the excretion of water without electrolyte loss.[1] Aquaretics are not strictly speaking diuretics, but are sometimes classified as such. Aquaresis is preferable to diuresis in the treatment of hyponatremia. PharmacokineticsAquaretics increase urine output without increasing sodium and chloride excretion, thus causing an increase in urine whilst retaining electrolytes.[2] ExamplesA number of herbal medicines are classified as aquaretics, for example common horsetail or common nettle leaves.[3] Synthetic aquaretics are vasopressin receptor antagonists, such conivaptan, tolvaptan, demeclocycline and mozavaptan (OPC-31260), as well as lithium. Conivaptan hydrochloride and tolvaptan have been approved by the FDA for treating syndrome of inappropriate antidiuretic hormone (SIADH). [4][5] Mozavaptan is approved in Japan. References1. ^{{cite book|title=Principles of Ambulatory Medicine|author1=Nicholas H. Fiebach |author2=Lee Randol Barker |pages=1390|year=2007|publisher=Lippincott Williams & Wilkins|isbn=0-7817-6227-8}} {{antihypertensive-stub}}2. ^{{cite book|title=Phamacology|author1=George M. Brenner |author2=Craig W. Stevens |date=2013|publisher=Elsevier Inc|isbn=978-1455702824|pages=120–129}} 3. ^{{cite book|title=Herbal Medicinals: A Clinician's Guide|author1=Lucinda G. Miller |author2=Wallace J. Murray |date=1998|publisher=Haworth Press|isbn=0-7890-0466-6|pages=147}} 4. ^{{cite web |url= https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021697lbl.pdf |title= Vaprisol|author= |date= 31 December 2005 |website= fda.gov|publisher= |access-date= 6 January 2019|quote=}} 5. ^ {{cite web |url=https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022275lbl.pdf |title= Samsca |author= |date= 31 May 2009 |website= fda.gov |publisher= |access-date= 6 January 2019 |quote=}} 1 : Diuretics |
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