“Arogenate dehydrogenase”的意思、由来-开放百科全书

词条

Arogenate dehydrogenase

释义

Structural studies
References

{{enzyme
| Name = cyclohexadienyl dehydrogenase
| EC_number = 1.3.1.43
| CAS_number = 64295-75-6
| IUBMB_EC_number = 1/3/1/43
| GO_code = 0047794
| image =
| width =
| caption =
}}

In enzymology, an arogenate dehydrogenase ({{EC number|1.3.1.43}}) is an enzyme that catalyzes the chemical reaction

L-arogenate + NAD⁺ L-tyrosine + NADH + CO₂

Thus, the two substrates of this enzyme are L-arogenate and NAD⁺, whereas its 3 products are L-tyrosine, NADH, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arogenate:NAD+ oxidoreductase (decarboxylating). Other names in common use include arogenic dehydrogenase (ambiguous), cyclohexadienyl dehydrogenase, pretyrosine dehydrogenase (ambiguous), and L-arogenate:NAD+ oxidoreductase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and novobiocin biosynthesis.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|2F1K}}.

References

{{cite journal | vauthors = Stenmark SL, Pierson DL, Jensen RA, Glover GI | date = 1974 | title = Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway | journal = Nature | volume = 247 | pages = 290–2 | pmid = 4206476 | doi = 10.1038/247290a0 | issue = 439 }}
{{cite journal | vauthors = Byng G, Whitaker R, Flick C, Jensen RA | last-author-amp = yes | date = 1981 | title = Enzymology of L-tyrosine biosynthesis in corn (Zea mays) | journal = Phytochemistry | volume = 20 | pages = 1289–1292 | doi = 10.1016/0031-9422(81)80023-4 | issue = 6 }}
{{cite journal | vauthors = Mayer E, Waldner-Sander S, Keller B, Keller E, Lingens F | date = 1985 | title = Purification of arogenate dehydrogenase from Phenylobacterium immobile | journal = FEBS Lett. | volume = 179 | pages = 208–12 | pmid = 3967752 | doi = 10.1016/0014-5793(85)80519-6 | issue = 2 }}
{{cite journal | vauthors = Lingens F, Keller E, Keller B | last-author-amp = yes | date = 1987 | title = Arogenate dehydrogenase from Phenylobacterium immobile | journal = Methods Enzymol. | volume = 142 | pages = 513–518 | doi = 10.1016/S0076-6879(87)42064-8 | series = Methods in Enzymology | isbn = 978-0-12-182042-8 }}
{{cite journal | vauthors = Zamir LO, Tiberio R, Devor KA, Sauriol F, Ahmad S, Jensen RA | date = 1988 | title = Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa | journal = J. Biol. Chem. | volume = 263 | pages = 17284–90 | pmid = 2972718 | issue = 33 }}

3 : EC 1.3.1|NADH-dependent enzymes|Enzymes of known structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。