| 词条 | Artesunate/amodiaquine |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 477236629 | type = combo | component1 = Artesunate | class1 = Antimalarial | component2 = Amodiaquine | class2 = Antimalarial | tradename = Camoquin, others[1] | pregnancy_AU = | pregnancy_US = C | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 944945-14-6 | ATCvet = | ATC_prefix = P01 | ATC_suffix = BF03 | PubChem = | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref= {{chemspidercite|correct|chemspider}} | ChemSpiderID = none | synonyms = ASAQ }}Artesunate/amodiaquine, sold under the trade name Camoquin among others, is a medication used for the treatment of malaria.[2] It is a fixed-dose combination of artesunate and amodiaquine.[1] Specifically it recommended for acute uncomplicated Plasmodium falciparum malaria.[2] It is taken by mouth.[5] Common side effects include loss of appetite, nausea, abdominal pain, sleepiness, trouble sleeping, and cough.[6] Safety in pregnancy is not clear; however, the medication may be used if others are not possible.[6] It is believed to be safe for use during breastfeeding.[6] Artesunate and amodiaquine are both antimalarial medication; however, work by different mechanisms.[3] Artesunate/amodiaquine was commercially launched in 2007.[4] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] Artesunate/amodiaquine is available as a generic medication.[4] The wholesale cost in the developing world is about US$0.85 to US$1.52 for a course of treatment.[6] As of 2014 it is not commercially available in the United States or United Kingdom.[7][8] Medical usesEarly clinical trials showed that a once-a-day dosage was effective.[9] It was subsequently clinically shown to be equally effective as artemether/lumefantrine,[10] although it is likely to be more effective in the field due to its simpler once-a-day dosage compared to artemether/lumefantrine twice-per-day dosage. Society and cultureArtesunate/amodiaquine was commercially launched in 2007 as an affordable treatment for malaria, devised by DNDi in partnership with Sanofi-Aventis.[4] References1. ^1 {{cite book|title=The selection and use of essential medicines: Twentieth report of the WHO Expert Committee 2015 (including 19th WHO Model List of Essential Medicines and 5th WHO Model List of Essential Medicines for Children).|date=2015|publisher=WHO|isbn=9789240694941|pages=435|url=http://apps.who.int/iris/bitstream/10665/189763/1/9789241209946_eng.pdf?ua=1|accessdate=8 December 2016|deadurl=no|archiveurl=https://web.archive.org/web/20161220085929/http://apps.who.int/iris/bitstream/10665/189763/1/9789241209946_eng.pdf?ua=1|archivedate=20 December 2016|df=}} 2. ^{{cite book|title=WHO Model Formulary 2008|date=2009|publisher=World Health Organization|isbn=9789241547659|page=187|url=http://apps.who.int/medicinedocs/documents/s16879e/s16879e.pdf|accessdate=8 December 2016|deadurl=no|archiveurl=https://web.archive.org/web/20161213060118/http://apps.who.int/medicinedocs/documents/s16879e/s16879e.pdf|archivedate=13 December 2016|df=}} 3. ^1 2 3 {{cite web|title=Artesunate Amodiaquine Winthrop|url=http://www.wipo.int/export/sites/www/research/en/data/sanofi/marketed_products/Artesunate_and_Amodiquine.pdf|website=WIPO|accessdate=12 December 2016|date=August 2010|deadurl=no|archiveurl=https://web.archive.org/web/20161024090154/http://www.wipo.int/export/sites/www/research/en/data/sanofi/marketed_products/Artesunate_and_Amodiquine.pdf|archivedate=24 October 2016|df=}} 4. ^1 2 {{cite web|title=New, Once-a-Day Fixed-Dose Combination Against Malaria Now Available – DNDi|url=http://www.dndi.org/2007/media-centre/press-releases/new-once-a-day-fixed-dose-combination-against-malaria-now-available/|website=www.dndi.org|accessdate=12 December 2016|date=1 March 2007|deadurl=no|archiveurl=https://web.archive.org/web/20161220123856/http://www.dndi.org/2007/media-centre/press-releases/new-once-a-day-fixed-dose-combination-against-malaria-now-available/|archivedate=20 December 2016|df=}} 5. ^{{cite web|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015|deadurl=no|archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|archivedate=13 December 2016|df=}} 6. ^1 {{cite web|title=Artesunate + Amodiaquine|url=http://mshpriceguide.org/en/single-drug-information/?DMFId=1447&searchYear=2014|website=International Drug Price Indicator Guide|accessdate=8 December 2016}} 7. ^1 {{cite book|last1=Ainsworth|first1=Sean B.|title=Neonatal Formulary: Drug Use in Pregnancy and the First Year of Life|date=2014|publisher=John Wiley & Sons|isbn=9781118819517|page=75|url=https://books.google.ca/books?id=EORvBAAAQBAJ&pg=PA75|language=en|deadurl=no|archiveurl=https://web.archive.org/web/20161220094547/https://books.google.ca/books?id=EORvBAAAQBAJ&pg=PA75|archivedate=2016-12-20|df=}} 8. ^{{cite book|last1=Goldman|first1=Lee|last2=Schafer|first2=Andrew I.|title=Goldman-Cecil Medicine|date=2015|publisher=Elsevier Health Sciences|isbn=9780323322850|page=2112|url=https://books.google.ca/books?id=40Z9CAAAQBAJ&pg=PA1354|language=en|deadurl=no|archiveurl=https://web.archive.org/web/20161220094525/https://books.google.ca/books?id=40Z9CAAAQBAJ&pg=PA1354|archivedate=2016-12-20|df=}} 9. ^{{cite journal|last=Ndiaye|title=Randomized, multicentre assessment of the efficacy and safety of ASAQ – a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria|journal=Malaria Journal|volume=8|pages=125|date=June 2009|url=http://www.malariajournal.com/content/8/1/125|accessdate=18 January 2013|doi=10.1186/1475-2875-8-125|pmid=19505304|pmc=2698916|first1=Jean|last2=Randrianarivelojosia|first2=Milijaona|last3=Sagara|first3=Issaka|last4=Brasseur|first4=Philippe|last5=Ndiaye|first5=Ibrahima|last6=Faye|first6=Babacar|last7=Randrianasolo|first7=Laurence|last8=Ratsimbasoa|first8=Arsène|last9=Forlemu|first9=Doris|last10=Moor|first10=Vicky|last11=Traore|first11=Aminata|last12=Dicko|first12=Yahia|last13=Dara|first13=Niawanlou|last14=Lameyre|first14=Valérie|last15=Diallo|first15=Mouctar|last16=Djimde|first16=Abdoulaye|last17=Same-Ekobo|first17=Albert|last18=Gaye|first18=Oumar|deadurl=no|archiveurl=https://web.archive.org/web/20110919234754/http://www.malariajournal.com/content/8/1/125|archivedate=19 September 2011|df=}} 10. ^{{cite journal|last=Nidiaye|title=Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trial|url=http://www.malariajournal.com/content/10/1/237|journal=Malaria Journal|volume=10|pages=237|accessdate=18 January 2013|doi=10.1186/1475-2875-10-237|pmid=21838909|pmc=3171378|year=2011|first1=Jean-Louis A|last2=Faye|first2=Babacar|last3=Gueye|first3=Ali|last4=Tine|first4=Roger|last5=Ndiaye|first5=Daouda|last6=Tchania|first6=Corinne|last7=Ndiaye|first7=Ibrahima|last8=Barry|first8=Aichatou|last9=Cissé|first9=Badara|last10=Lameyre|first10=Valérie|last11=Gaye|first11=Oumar|deadurl=no|archiveurl=https://web.archive.org/web/20141010194457/http://www.malariajournal.com/content/10/1/237|archivedate=10 October 2014|df=}} External links
4 : Antimalarial agents|Combination drugs|World Health Organization essential medicines|RTT |
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