“Asparagine—tRNA ligase”的意思、由来-开放百科全书

词条

Asparagine—tRNA ligase

释义

Structural studies
References

{{enzyme
| Name = asparagine-tRNA ligase
| EC_number = 6.1.1.22
| CAS_number = 37211-76-0
| IUBMB_EC_number = 6/1/1/22
| GO_code = 0004816
| image =
| width =
| caption =
}}

In enzymology, an asparagine-tRNA ligase ({{EC number|6.1.1.22}}) is an enzyme that catalyzes the chemical reaction

ATP + L-asparagine + tRNAAsn AMP + diphosphate + L-asparaginyl-tRNAAsn

The 3 substrates of this enzyme are ATP, L-asparagine, and tRNA(Asn), whereas its 3 products are AMP, diphosphate, and L-asparaginyl-tRNA(Asn).

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-asparagine:tRNAAsn ligase (AMP-forming). Other names in common use include asparaginyl-tRNA synthetase, asparaginyl-transfer ribonucleate synthetase, asparaginyl transfer RNA synthetase, asparaginyl transfer ribonucleic acid synthetase, asparagyl-transfer RNA synthetase, and asparagine translase. This enzyme participates in alanine and aspartate metabolism and aminoacyl-trna biosynthesis.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1X54}}, {{PDB link|1X55}}, and {{PDB link|1X56}}.

References

{{cite journal |vauthors=Davies MR, Marshall RD | year = 1972 | title = Partial purification of L-asparaginyl-tRNA synthetase from rabbit liver | journal = Biochem. Biophys. Res. Commun. | volume = 47 | pages = 1386–95 | pmid = 5040239 | doi = 10.1016/0006-291X(72)90226-4 | issue = 6 }}

{{Ligases CO CS and CN}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Asparagine-tRNA ligase}}{{ligase-stub}}

2 : EC 6.1.1|Enzymes of known structure

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