“Asparaginyl-tRNA synthase (glutamine-hydrolysing)”的意思、由来-开放百科全书

词条

Asparaginyl-tRNA synthase (glutamine-hydrolysing)

释义

References

{{enzyme
| Name = asparaginyl-tRNA synthase (glutamine-hydrolyzing)
| EC_number = 6.3.5.6
| CAS_number = 37211-76-0
| IUBMB_EC_number = 6/3/5/6
| GO_code = 0050566
| image =
| width =
| caption =
}}

In enzymology, an asparaginyl-tRNA synthase (glutamine-hydrolysing) ({{EC number|6.3.5.6}}) is an enzyme that catalyzes the chemical reaction

ATP + aspartyl-tRNAAsn + L-glutamine ADP + phosphate + asparaginyl-tRNAAsn + L-glutamate

The 3 substrates of this enzyme are ATP, aspartyl-tRNA(Asn), and L-glutamine, whereas its 4 products are ADP, phosphate, asparaginyl-tRNA(Asn), and L-glutamate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming). Other names in common use include Asp-AdT, Asp-tRNAAsn amidotransferase, aspartyl-tRNAAsn amidotransferase, and Asn-tRNAAsn:L-glutamine amido-ligase (ADP-forming). This enzyme participates in glutamate metabolism and alanine and aspartate metabolism.

References

{{cite journal | vauthors = Min B, Pelaschier JT, Graham DE, Tumbula-Hansen D, Soll D | year = 2002 | title = Transfer RNA-dependent amino acid biosynthesis: an essential route to asparagine formation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | pages = 2678–83 | pmid = 11880622 | doi = 10.1073/pnas.012027399 | issue = 5 | pmc = 122407 }}
{{cite journal | vauthors = Curnow AW, Tumbula DL, Pelaschier JT, Min B, Soll D | year = 1998 | title = Glutamyl-tRNA(Gln) amidotransferase in Deinococcus radiodurans may be confined to asparagine biosynthesis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | pages = 12838–43 | pmid = 9789001 | doi = 10.1073/pnas.95.22.12838 | issue = 22 | pmc = 23620 }}
{{cite journal | vauthors = Ibba M, Soll D | year = 2000 | title = Aminoacyl-tRNA synthesis | journal = Annu. Rev. Biochem. | volume = 69 | issue = 1 | pages = 617–50 | pmid = 10966471 | doi = 10.1146/annurev.biochem.69.1.617 }}

2 : EC 6.3.5|Enzymes of unknown structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。