1. Function

2. See also

3. Interactions

4. References

5. Further reading

6. External links

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene^[1][2][3] and is involved in the unfolded protein response.

Function

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.^[4] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

See also

• Activating transcription factor

Interactions

ATF6 has been shown to interact with YY1^[5] and Serum response factor.^[2]

References

Further reading

• {{cite journal | vauthors = Hai T, Hartman MG | title = The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis | journal = Gene | volume = 273 | issue = 1 | pages = 1–11 | year = 2001 | pmid = 11483355 | doi = 10.1016/S0378-1119(01)00551-0 }}
• {{cite journal | vauthors = Hai TW, Liu F, Coukos WJ, Green MR | title = Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers | journal = Genes Dev. | volume = 3 | issue = 12B | pages = 2083–90 | year = 1990 | pmid = 2516827 | doi = 10.1101/gad.3.12b.2083 }}
• {{cite journal | vauthors = Zhu C, Johansen FE, Prywes R | title = Interaction of ATF6 and serum response factor | journal = Mol. Cell. Biol. | volume = 17 | issue = 9 | pages = 4957–66 | year = 1997 | pmid = 9271374 | pmc = 232347 | doi = 10.1128/MCB.17.9.4957}}
• {{cite journal | vauthors = Yoshida H, Haze K, Yanagi H, Yura T, Mori K | title = Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors | journal = J. Biol. Chem. | volume = 273 | issue = 50 | pages = 33741–9 | year = 1999 | pmid = 9837962 | doi = 10.1074/jbc.273.50.33741 }}
• {{cite journal | vauthors = Haze K, Yoshida H, Yanagi H, Yura T, Mori K | title = Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress | journal = Mol. Biol. Cell | volume = 10 | issue = 11 | pages = 3787–99 | year = 1999 | pmid = 10564271 | pmc = 25679 | doi = 10.1091/mbc.10.11.3787 }}
• {{cite journal | vauthors = Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS | title = ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1 | journal = Mol. Cell. Biol. | volume = 20 | issue = 14 | pages = 5096–106 | year = 2000 | pmid = 10866666 | pmc = 85959 | doi = 10.1128/MCB.20.14.5096-5106.2000 }}
• {{cite journal | vauthors = Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K | title = Endoplasmic Reticulum Stress-Induced Formation of Transcription Factor Complex ERSF Including NF-Y (CBF) and Activating Transcription Factors 6α and 6β That Activates the Mammalian Unfolded Protein Response | journal = Mol. Cell. Biol. | volume = 21 | issue = 4 | pages = 1239–48 | year = 2001 | pmid = 11158310 | pmc = 99577 | doi = 10.1128/MCB.21.4.1239-1248.2001 }}
• {{cite journal | vauthors = Ye J, Rawson RB, Komuro R, Chen X, Davé UP, Prywes R, Brown MS, Goldstein JL | title = ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs | journal = Mol. Cell | volume = 6 | issue = 6 | pages = 1355–64 | year = 2001 | pmid = 11163209 | doi = 10.1016/S1097-2765(00)00133-7 }}
• {{cite journal | vauthors = Parker R, Phan T, Baumeister P, Roy B, Cheriyath V, Roy AL, Lee AS | title = Identification of TFII-I as the Endoplasmic Reticulum Stress Response Element Binding Factor ERSF: Its Autoregulation by Stress and Interaction with ATF6 | journal = Mol. Cell. Biol. | volume = 21 | issue = 9 | pages = 3220–33 | year = 2001 | pmid = 11287625 | pmc = 86961 | doi = 10.1128/MCB.21.9.3220-3233.2001 }}
• {{cite journal | vauthors = Gotoh T, Oyadomari S, Mori K, Mori M | title = Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP | journal = J. Biol. Chem. | volume = 277 | issue = 14 | pages = 12343–50 | year = 2002 | pmid = 11805088 | doi = 10.1074/jbc.M107988200 }}
• {{cite journal | vauthors = Chen X, Shen J, Prywes R | title = The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi | journal = J. Biol. Chem. | volume = 277 | issue = 15 | pages = 13045–52 | year = 2002 | pmid = 11821395 | doi = 10.1074/jbc.M110636200 }}
• {{cite journal | vauthors = Thuerauf DJ, Morrison LE, Hoover H, Glembotski CC | title = Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16 | journal = J. Biol. Chem. | volume = 277 | issue = 23 | pages = 20734–9 | year = 2002 | pmid = 11909875 | doi = 10.1074/jbc.M201749200 }}
• {{cite journal | vauthors = Okada T, Yoshida H, Akazawa R, Negishi M, Mori K | title = Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response | journal = Biochem. J. | volume = 366 | issue = Pt 2 | pages = 585–94 | year = 2002 | pmid = 12014989 | pmc = 1222788 | doi = 10.1042/BJ20020391 }}
• {{cite journal | vauthors = Luo S, Lee AS | title = Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation | journal = Biochem. J. | volume = 366 | issue = Pt 3 | pages = 787–95 | year = 2002 | pmid = 12076252 | pmc = 1222838 | doi = 10.1042/BJ20011802 }}
• {{cite journal | vauthors = Tardif KD, Mori K, Siddiqui A | title = Hepatitis C Virus Subgenomic Replicons Induce Endoplasmic Reticulum Stress Activating an Intracellular Signaling Pathway | journal = J. Virol. | volume = 76 | issue = 15 | pages = 7453–9 | year = 2002 | pmid = 12097557 | pmc = 136367 | doi = 10.1128/JVI.76.15.7453-7459.2002 }}
• {{cite journal | vauthors = Shuda M, Kondoh N, Imazeki N, Tanaka K, Okada T, Mori K, Hada A, Arai M, Wakatsuki T, Matsubara O, Yamamoto N, Yamamoto M | title = Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis | journal = J. Hepatol. | volume = 38 | issue = 5 | pages = 605–14 | year = 2004 | pmid = 12713871 | doi = 10.1016/S0168-8278(03)00029-1 }}
• {{cite journal | vauthors = Okada T, Haze K, Nadanaka S, Yoshida H, Seidah NG, Hirano Y, Sato R, Negishi M, Mori K | title = A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6 | journal = J. Biol. Chem. | volume = 278 | issue = 33 | pages = 31024–32 | year = 2003 | pmid = 12782636 | doi = 10.1074/jbc.M300923200 }}
• {{cite journal | vauthors = Newman JR, Keating AE | title = Comprehensive identification of human bZIP interactions with coiled-coil arrays | journal = Science | volume = 300 | issue = 5628 | pages = 2097–101 | year = 2003 | pmid = 12805554 | doi = 10.1126/science.1084648 }}

External links

• {{MeshName|ATF6+protein,+human}}
• {{UCSC gene info|ATF6}}

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