| 词条 | Atypical antidepressant |
| 释义 |
An atypical antidepressant is a type of antidepressant medication which acts in an atypical manner relative to most other antidepressants. Examples of atypical antidepressants include mirtazapine, mianserin, bupropion, trazodone, nefazodone, tianeptine, opipramol, and agomelatine.[1][2][3] The agents vilazodone and vortioxetine are also partially atypical. Atypical antidepressants are as opposed to typical antidepressants like the {{abbrlink|SSRIs|selective serotonin reuptake inhibitors}}, {{abbrlink|SNRIs|serotonin-norepinephrine reuptake inhibitors}}, {{abbrlink|TCAs|tricyclic antidepressants}}, and {{abbrlink|MAOIs|monoamine oxidase inhibitors}}, which act mainly by increasing the levels of the monoamine neurotransmitters serotonin and/or norepinephrine.[1][2][3] Among TCAs, trimipramine is an atypical agent in that it does not appear to do this.[3] Esketamine (JNJ-54135419) and buprenorphine/samidorphan (ALKS-5461) are antidepressants with novel mechanisms of action which are under development and, at present, would be considered to be atypical antidepressants.[4] Unlike current agents, they are more rapidly-acting antidepressants.[4]See also
References1. ^1 {{cite journal | vauthors = Feighner JP | title = Mechanism of action of antidepressant medications | journal = J Clin Psychiatry | volume = 60 Suppl 4 | issue = | pages = 4–11; discussion 12–3 | year = 1999 | pmid = 10086478 | doi = | url = }} {{Antidepressants}}{{Nervous-system-drug-stub}}2. ^1 {{cite journal | vauthors = Stahl SM | title = Basic psychopharmacology of antidepressants, part 1: Antidepressants have seven distinct mechanisms of action | journal = J Clin Psychiatry | volume = 59 Suppl 4 | issue = | pages = 5–14 | year = 1998 | pmid = 9554316 | doi = | url = }} 3. ^1 2 {{cite journal | vauthors = Frazer A | title = Pharmacology of antidepressants | journal = J Clin Psychopharmacol | volume = 17 Suppl 1 | issue = | pages = 2S–18S | year = 1997 | pmid = 9090573 | doi = 10.1097/00004714-199704001-00002| url = }} 4. ^1 {{cite journal | vauthors = Garay RP, Zarate CA, Charpeaud T, Citrome L, Correll CU, Hameg A, Llorca PM | title = Investigational drugs in recent clinical trials for treatment-resistant depression | journal = Expert Rev Neurother | volume = 17 | issue = 6 | pages = 593–609 | year = 2017 | pmid = 28092469 | doi = 10.1080/14737175.2017.1283217 | pmc=5418088}} 1 : Antidepressants |
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