| 词条 | Benorilate |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 461759359 | IUPAC_name = 4-(acetylamino)phenyl 2-(acetyloxy)benzoate | image = Benorilate.svg | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Oral | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 5003-48-5 | ATC_prefix = N02 | ATC_suffix = BA10 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 162036 | PubChem = 21102 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = W1QX9DV96G | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 19846 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C17H15NO5/c1-11(19)18-13-7-9-14(10-8-13)23-17(21)15-5-3-4-6-16(15)22-12(2)20/h3-10H,1-2H3,(H,18,19) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = FEJKLNWAOXSSNR-UHFFFAOYSA-N | C=17 | H=15 | N=1 | O=5 | molecular_weight = 313.305 g/mol | smiles = O=C(C)Oc2ccccc2C(=O)Oc1ccc(NC(C)=O)cc1 }}Benorilate (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.[1] References1. ^Simila S, Keinanen S, Kouvalainen K.Oral antipyretic therapy: evaluation of benorylate, an ester of acetylsalicylic acid and paracetamol. Eur J Pediatr. 1975 Dec 9;121(1):15-20. {{PMID|2478}} {{Analgesics}}{{Anti-inflammatory and antirheumatic products}}{{Salicylates}}{{Prostanoidergics}}{{musculoskeletal-drug-stub}}{{analgesic-stub}} 3 : Analgesics|Antipyretics|Codrugs |
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