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词条 Benzamide
释义

  1. Chemical derivatives

  2. See also

  3. References

  4. External links

{{chembox
| Watchedfields = changed
| verifiedrevid = 443415079
| ImageFile = Benzamide.svg
| ImageSize = 170px
| ImageName = Skeletal formula
| ImageFile1 = Benzamide-3D-balls.png
| ImageName1 = Ball-and-stick model
| PIN = Benzamide[1]
| SystematicName = Benzenecarboxamide
| OtherNames = Benzoic acid amide
Phenyl carboxamide
Benzoylamide
|Section1={{Chembox Identifiers
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = C09815
| InChIKey = KXDAEFPNCMNJSK-UHFFFAOYAA
| SMILES1 = c1ccc(cc1)C(=O)N
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 267373
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = KXDAEFPNCMNJSK-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 55-21-0
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2241
| EINECS = 200-227-7
| PubChem = 2331
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 6X80438640
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 28179
| SMILES = O=C(N)c1ccccc1
| InChI = 1/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)
| RTECS = CU8700000
|Section2={{Chembox Properties
| C=7 | H=7 | N=1 | O=1
| Appearance = Off-white solid
| Density = 1.341 g/cm3
| MeltingPtC = 127 to 130
| MeltingPt_notes =
| BoilingPtC = 288
| Solubility = 13 g/l
| pKa = {{ubl
| approx. 13 (H2O)[2]
| 23.3 (DMSO)[3]
}}
| MagSus = -72.3·10−6 cm3/mol
|Section6={{Chembox Pharmacology
| ATCCode_prefix = N05
| ATCCode_suffix = AL
}}
|Section7={{Chembox Hazards
| EUClass = Harmful (Xn)
| MainHazards =
| FlashPtC = 180
| AutoignitionPt = >
| AutoignitionPtC = 500
| NFPA-H = 1
| NFPA-F = 1
| NFPA-R = 0
| NFPA-S =
| RPhrases = {{R22}} {{R40}}
| SPhrases = {{S36/37/39}}
}}

Benzamide is an off-white solid with the chemical formula of C7H7NO. It is a derivative of benzoic acid. It is slightly soluble in water, and soluble in many organic solvents.

Chemical derivatives

A number of substituted benzamides exist, including:

{{Columns-list|colwidth=22em|
Analgesics
  • Ethenzamide
  • Salicylamide
  • Salverine
Antidepressants
  • Moclobemide
Antiemetics/Prokinetics
  • Alizapride
  • Batanopride
  • Bromopride
  • Cinitapride
  • Cisapride
  • Clebopride
  • Dazopride
  • Itopride
  • Metoclopramide
  • Mosapride
  • Prucalopride
  • Renzapride
  • Trimethobenzamide
  • Zacopride
Antipsychotics
  • Azapride
  • Amisulpride
  • Levosulpiride
  • Nemonapride
  • Remoxipride
  • Sulpiride
  • Sultopride
  • Tiapride
Opioids
  • AH-7921
  • Bromadoline
  • U-47700
  • U-77891
Others
  • 3-Aminobenzamide
  • Chidamide
  • Denipride
  • Entinostat
  • Eticlopride
  • Mocetinostat
  • Procarbazine
  • Pyramide (pyridinyl ethylbenzimide)[4]
  • Raclopride
  • Sunifiram

}}

See also

  • ATC code N05AL Benzamides

References

1. ^{{cite book | title = Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book) | publisher = The Royal Society of Chemistry | date = 2014 | location = Cambridge | page = 841 | doi = 10.1039/9781849733069-FP001 | isbn = 978-0-85404-182-4}}
2. ^{{cite book | editor= Haynes, William M. | year = 2016 | title = CRC Handbook of Chemistry and Physics | edition = 97th | publisher = CRC Press | isbn = 978-1498754286 | page=5–89 | title-link = CRC Handbook of Chemistry and Physics }}
3. ^{{cite journal |last1=Bordwell |first1=Frederick G. |last2=Ji |first2=Guo Zhen |title=Effects of structural changes on acidities and homolytic bond dissociation energies of the hydrogen-nitrogen bonds in amidines, carboxamides, and thiocarboxamides |journal=Journal of the American Chemical Society |date=October 1991 |volume=113 |issue=22 |pages=8398–8401 |doi=10.1021/ja00022a029}}
4. ^{{Cite book|author1=Singh, K. N. |author2=Merchant, Kavita |lastauthoramp=yes |chapter=The Agrochemical Industry, Annex 17.1|year=2012|editor=Kent, James A.|title=Handbook of Industrial Chemistry and Biotechnology|location=New York|publisher=Springer Verlag|pages=643–698 [https://books.google.com/books?id=7VxDAAAAQBAJ&pg=PA693 page 693]|isbn=|doi=10.1007/978-1-4614-4259-2_17}}

External links

  • [https://web.archive.org/web/20060827012038/http://www.chemicalland21.com/industrialchem/organic/BENZAMIDE.htm Physical characteristics]
  • Safety MSDS data
{{Antipsychotics}}{{Antiemetics}}{{Propulsives}}{{Analgesics}}{{Authority control}}

2 : Benzamides|Phenyl compounds

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