| 词条 | Benzamidine |
| 释义 |
| Watchedfields = changed | verifiedrevid = 443415204 | ImageFile = Benzamidine.svg | ImageSize = 160px | ImageName = Skeletal formula | ImageFile1 = Benzamidine-3D-balls.png | ImageSize1 = 160px | ImageName1 = Ball-and-stick model | IUPACName=Benzenecarboximidamide | OtherNames= |Section1={{Chembox Identifiers | IUPHAR_ligand = 7566 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2242 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = C01784 | InChI = 1/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9) | InChIKey = PXXJHWLDUBFPOL-UHFFFAOYAU | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 20936 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = PXXJHWLDUBFPOL-UHFFFAOYSA-N | CASNo_Ref = {{cascite|correct|CAS}} | CASNo=618-39-3 | PubChem=2332 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 41033 | SMILES = [NH]=C(N)c1ccccc1 }} |Section2={{Chembox Properties | C=7 | H=8 | N=2 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Benzamidine is a reversible competitive inhibitor of trypsin, trypsin-like enzymes and serine proteases.[1] It is often used as a ligand in protein crystallography to prevent proteases from degrading a protein of interest; the triangular diamine group at the bottom gives it a very obvious 'stick-man' shape which shows up in difference density maps. The benzamidine moiety is also found in some pharmaceuticals, like dabigatran. References1. ^{{Cite journal|last=Tanizawa|first=Kazutaka|last2=Ishii|first2=Shin-ichi|last3=Hamaguchi|first3=Kazo|last4=Kanaoka|first4=Yuichi|date=1971-05-01|title=Proteolytic EnzymesVI. Aromatic Amidines as Competitive Inhibitors of Trypsin|url=https://academic.oup.com/jb/article/69/5/893/2184754/Proteolytic-EnzymesVI-Aromatic-Amidines-as|journal=The Journal of Biochemistry|volume=69|issue=5|pages=893–899|doi=10.1093/oxfordjournals.jbchem.a129540|issn=0021-924X}} {{Organic-compound-stub}} 2 : Phenyl compounds|Amidines |
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