“Benzoylformate decarboxylase”的意思、由来-开放百科全书

词条

Benzoylformate decarboxylase

释义

Structural studies
References

{{enzyme
| Name = benzoylformate decarboxylase
| EC_number = 4.1.1.7
| CAS_number = 9025-00-7
| IUBMB_EC_number = 4/1/1/7
| GO_code = 0050695
| image = 4mzx.jpg
| width = 270
| caption = Benzoylformate decarboxlyase tetramer, Pseudomonas putida
}}

In enzymology, a benzoylformate decarboxylase ({{EC number|4.1.1.7}}) is an enzyme that catalyzes the following chemical reaction:

benzoylformate + H⁺ benzaldehyde + CO₂

Hence, this enzyme has one substrate, benzoylformate, and two products, benzaldehyde and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is benzoylformate carboxy-lyase (benzaldehyde-forming). Other names in common use include phenylglyoxylate decarboxylase, and benzoylformate carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation and toluene and xylene degradation. It employs one cofactor, thiamin diphosphate.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1BFD}}, {{PDB link|1MCZ}}, {{PDB link|1PI3}}, {{PDB link|1PO7}}, {{PDB link|1Q6Z}}, {{PDB link|1YNO}}, {{PDB link|2FN3}}, and {{PDB link|2FWN}}.

References

{{cite journal | vauthors = GUNSALUS CF, STANIER RY, GUNSALUS IC | date = 1953 | title = The enzymatic conversion of mandelic acid to benzoic acid. III Fractionation and properties of the soluble enzymes | journal = J. Bacteriol. | volume = 66 | pages = 548–53 | pmid = 13108854 | issue = 5 | pmc = 317432 }}

3 : EC 4.1.1|Thiamine enzymes|Enzymes of known structure

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