| 词条 | Benzylthiouracil |
| 释义 |
| Watchedfields = changed | verifiedrevid = 462791352 | IUPAC_name = 1-(1-cyclohexa-2,4-dienylmethyl)-7-thia- 3,5-diazabicyclo[4.1.0]hepta-3,5-dien-2-one | image = Benzylthiouracil.svg | tradename = | Drugs.com = {{drugs.com|international|benzylthiouracil}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Oral | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = Renal | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 6336-50-1 | ATC_prefix = H03 | ATC_suffix = BA03 | PubChem = 685814 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = PZ35LUM333 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 597542 | ChEMBL = 1491306 | smiles = S=C1N/C(=C\\C(=O)N1)Cc2ccccc2 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C11H10N2OS/c14-10-7-9(12-11(15)13-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H2,12,13,14,15) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = PNXBXCRWXNESOV-UHFFFAOYSA-N | C=11 | H=10 | N=2 | O=1 | S=1 | molecular_weight = 218.276 g/mol }} Benzylthiouracil (BTU) is an antithyroid preparation. It is a thioamide, closely related to propylthiouracil. Adverse effectsBenzylthiouracil has been associated with severe adverse effects, notably vasculitis and subsequent ANCA-positive glomerulonephritis, as well as isolated reports of lung damage.[1][2][3][4] References1. ^{{cite journal |vauthors=Tieulie N, Huong DL, Andreu M |title=[ANCA associated glomerulonephritis related to benzylthiouracil] |language=French |journal=Rev Med Interne |volume=23 |issue=10 |pages=853–6 |year=2002 |pmid=12428489 |doi=10.1016/S0248-8663(02)00694-X|display-authors=etal}} {{Thyroid therapy}}{{Thyroid hormone receptor modulators}}{{systemic-hormonal-drug-stub}}2. ^{{cite journal |vauthors=Kaaroud H, Khiari K, Ben Moussa F, Barbouch S, Boussema E, Ben Maïz H |title=[Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for Graves disease] |language=French |journal=Rev Med Interne |volume=23 |issue=10 |pages=857–61 |year=2002 |pmid=12428490 |doi=10.1016/S0248-8663(02)00704-X}} 3. ^{{cite journal |vauthors=Braham A, Houman MH, Rais L, Ben Gborbel I, Lamloum M, Miled M |title=[Benzylthiouracil induced ANCA-positive vasculitis] |language=French |journal=Presse Médicale |volume=33 |issue=19 Pt 1 |pages=1331–3 |year=2004 |pmid=15615240 |doi=10.1016/S0755-4982(04)98919-1}} 4. ^{{cite journal |vauthors=Thabet F, Sghiri R, Tabarki B, Ghedira I, Yacoub M, Essoussi AS |title=ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil |journal=Eur J Pediatr |volume=165 |issue=7 |pages=435–6 |year=2006 |pmid=16622664 |doi=10.1007/s00431-005-0053-4}} 4 : Antithyroid drugs|Pyrimidines|Thioureas|Nucleobases |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。