“Berberine reductase”的意思、由来-开放百科全书

词条

Berberine reductase

释义

References

{{enzyme
| Name = berberine reductase
| EC_number = 1.5.1.31
| CAS_number =
| IUBMB_EC_number = 1/5/1/31
| GO_code = 0050623
| image =
| width =
| caption =
}}Berberine reductase ({{EC number|1.5.1.31}}) is an enzyme that catalyzes the chemical reaction

(R)-canadine + 2 NADP⁺ berberine + 2 NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-canadine and nicotinamide adenine dinucleotide phosphate ion, whereas its 3 products are berberine, nicotinamide adenine dinucleotide phosphate, and hydrogen ion.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-tetrahydroberberine:NADP+ oxidoreductase. This enzyme is also called (R)-canadine synthase.

References

{{cite journal |author1 = Bauer W |author2 =Zenk MH | date = 1991 | title = Formation of (R)-configurated tetrahydroprotoberberine alkaloids in vivo and in vitro | journal = Tetrahedron Lett. | volume = 32 | pages = 487–490 | doi = 10.1016/S0040-4039(00)79475-5 | issue = 4 }}

{{CH-NH oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}Flavin reduktaza

3 : EC 1.5.1|NADPH-dependent enzymes|Enzymes of unknown structure

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