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词条 Bert Vogelstein
释义

  1. Research

  2. Citations

  3. Awards

  4. Affiliations

  5. References

  6. External links

{{Infobox scientist
| name = Bert Vogelstein
| image = Bert Vogelstein giving the Trent Lecture.jpg
| image_size =
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| birth_date = {{Birth date and age|1949|06|02}}
| birth_place = Baltimore, Maryland
| death_date =
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| nationality =
| fields = Oncology, Pediatrics
| workplaces = Johns Hopkins School of Medicine
| alma_mater = University of Pennsylvania
Johns Hopkins School of Medicine
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| notable_students =
| known_for = p53, Vogelgram, somatic evolution in cancer
| children = Joshua Vogelstein, Jacob Vogelstein
| author_abbrev_bot =
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| influences =
| influenced =
| awards = Breakthrough Prize in Life Sciences {{small|(2013)}}[1]
Warren Triennial Prize {{small|(2014)}}[2]
| signature =
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| website = {{URL|http://www.hhmi.org/research/investigators/vogelstein_bio.html}}
| footnotes =
| spouse = Ilene Vogelstein
}}

Bert Vogelstein (born 1949) is Director of the Ludwig Center, Clayton Professor of Oncology and Pathology and a Howard Hughes Medical Institute investigator at The Johns Hopkins Medical School and Sidney Kimmel Comprehensive Cancer Center.[3] A pioneer in the field of cancer genomics, his studies on colorectal cancers revealed that they result from the sequential accumulation of mutations in oncogenes and tumor suppressor genes. These studies now form the paradigm for modern cancer research and provided the basis for the notion of the somatic evolution of cancer. Together with Martin Nowak at Harvard University, he developed many mathematical models to understand the evolutionary process of cancer which lead to various hypotheses about mechanisms and timing of progression and seeding of metastases.

Research

In the 1980s, Vogelstein developed new experimental approaches to study human tumors.[4] His studies of various stages of colorectal cancers led him to propose a specific model for human tumorigenesis in 1988. In particular, he suggested that "cancer is caused by sequential mutations of specific oncogenes and tumor suppressor genes".[5][6][7]

The first tumor suppressor gene validating this hypothesis was that encoding p53. The p53 protein was discovered 10 years earlier by several groups, including that of David Lane and Lionel Crawford, Arnold Levine, and Lloyd Old. But there was no evidence that p53 played a major role in human cancers, and the gene encoding p53 (TP53) was thought to be an oncogene rather than a tumor suppressor gene. In 1989, Vogelstein and his students discovered that TP53 not only played a role in human tumorigenesis, but that it was a common denominator of human tumors, mutated in the majority of them.[8][9] He then discovered the mechanism through which TP53 suppresses tumorigenesis. Prior to these studies, the only biochemical function attributed to p53 was its binding to heat shock proteins. Vogelstein and his colleagues demonstrated that p53 had a much more specific activity: it bound DNA in a sequence-specific manner. They precisely defined its consensus recognition sequence and showed that virtually all p53 mutations found in tumors resulted in loss of the sequence-specific transcriptional activation properties of p53.[10][11] They subsequently discovered genes that are directly activated by p53 to control cell birth and cell death.[12][13] His group's more recent studies examining the entire compendium of human genes have shown that the TP53 gene is more frequently mutated in cancers than any other gene.[14][15][11][16][17][18]

In 1991, Vogelstein and long-time colleague Kenneth W. Kinzler, working with Yusuke Nakamura in Japan, discovered another tumor suppressor gene. This gene, called APC, was responsible for Familial Adenomatous Polyposis (FAP), a syndrome associated with the development of numerous small benign tumors, some of which progress to cancer.[19][20] This gene was independently discovered by Ray White's group at the University of Utah. Vogelstein and Kinzler subsequently showed that non-hereditary (somatic) mutations of APC initiate most cases of colon and rectal cancers. They also showed how APC functions - through binding to beta-catenin and stimulating its degradation.[21][22]

Vogelstein and Kinzler worked with Albert de la Chapelle and Lauri Aaltonen at the U. Helsinki to identify the genes responsible for Hereditary NonPolyposis Colorectal Cancer (HNPCC), the other major form of heritable colorectal tumorigenesis. They were the first to localize one of the major causative genes to a specific chromosomal locus through linkage studies. This localization soon led them and other groups to identify repair genes such as MSH2 and MLH1 that are responsible for most cases of this syndrome.[23][24][25][26]

Beginning in 2004, Vogelstein and Kinzler, working with Victor Velculescu, Nicholas Papadopoulos and others in their group, began to perform large scale experiments to identify mutations throughout the genome. They were the first to perform "exomic sequencing", meaning determination of the sequence of every protein-encoding gene in the human genome. The first analyzed tumors included those of the colon, breast, pancreas, and brain. These studies outlined the landscapes of human cancer genomes, later confirmed by massively parallel sequencing of many different tumor types by laboratories throughout the world.[27] In the process of analyzing all the protein-encoding genes within cancers, Vogelstein and his colleagues discovered several novel genes that play important roles in cancer, such as PIK3CA,[28] IDH1,[29] IDH2,[29] ARID1A,[30] ARID2, ATRX,[31] DAXX,[31] MLL2, MLL3, CIC, and RNF43.[32][33][34][35]

Vogelstein pioneered the idea that somatic mutations represent uniquely specific biomarkers for cancer, creating the field now called "liquid biopsies". Working with post-doctoral fellow David Sidransky in the early 90's, he showed showing that such mutations were detectable in the stool of colorectal cancer patients and the urine of bladder cancer patients.[36][37] For this purpose, they developed "Digital PCR" in which DNA molecules are examined one-by-one to determine whether they are normal or mutated.[38] One of the techniques they invented for Digital PCR is called "BEAMing", in which the PCR is carried out on magnetic beads in water-in-oil emulsions.[39] BEAMing is now one of the core technologies used in some next-generation, massively parallel sequencing instruments.More recently, they developed a digital-PCR based technique called SafeSeqS, in which every DNA template molecule is recognized by a unique molecular barcode. SafeSeqS dramatically enhances the ability to identify rare variants among DNA sequences, allowing such variants to be detected when they are present in only 1 in more than 10,000 total DNA molecules.[40][41][42][43][44]

In the mid 2000s, Vogelstein started collaborating with the group of Martin Nowak at Harvard University. Together with their groups, they developed mathematical models to explain the evolution of resistance against targeted therapies.[45] They showed that the sequential administration of multiple targeted drugs precludes any chance for cure — even when there are no possible mutations that can confer cross-resistance to both drugs.[46]

Citations

Vogelstein has published more than 500 scientific papers. Vogelstein’s research papers have been cited nearly 300,000 times, more often than those of any other scientist, in any discipline, in recorded history. If books in addition to research papers are included, Vogelstein is ranked as the 8th most cited scholar, just behind Noam Chomsky (7th), with Sigmund Freud ranking first.[47]

Awards

  • The Bristol Myers Squibb Award for "Distinguished Achievement in Cancer Research" (1990)[48]
  • The Young Investigator Award from the American Federation for Clinical Research (1992), now the American Federation for Medical Research
  • The Gairdner Foundation International Award in Science (1992)[49]
  • The American Cancer Society Medal of Honor (1992)
  • The Shacknai Memorial Prize from the Hebrew University (1993)[50]
  • The Dickson Prize from the University of Pittsburgh (1994)
  • The Pezcoller Foundation Award from the American Association for Cancer Research (1993)[51]
  • The Richard Lounsbery Award from the National Academy of Sciences (1993)
  • The Baxter Award from the Association of American Medical Colleges (1993)[52]
  • The Ernst Schering Prize (1994)
  • The Passano Award from the Passano Foundation(1994)[53]
  • The David A. Karnofsky Memorial Award from the American Society of Clinical Oncology (1995)[54]
  • The Karnofsky Memorial Award from the American Society for Clinical Oncology (1995)
  • The William Beaumont Prize in Gastroenterology from the American Gastroenterological Association (1997)[55]
  • The Louisa Gross Horwitz Prize (1998)
  • The Paul Ehrlich and Ludwig Darmstaedter Prize from the Paul Ehrlich Foundation (1998)
  • The William Allan Award from the American Society of Human Genetics (1998)
  • The Charles S. Mott Prize from the General Motors Cancer Research Foundation (2000)
  • The Harvey Prize in Human Health from the Technion (2001)
  • The John Scott Award from the John Scott Trust (2003)[56]
  • The Prince of Asturias Awards in Science (2004)[57]
  • The Charles Rodolphe Brupbacher Prize for Cancer Research (2011)[58]
  • The Howard Taylor Ricketts Award from the University of Chicago
  • The Clowes Memorial Award from the American Association for Cancer Research[59]
  • The New York Academy of Medicine Medal for Distinguished Contributions to Biomedical Science
  • The Pasarow Award for Medical Research
  • The Pioneer in Science Award from the American Research Forum
  • Breakthrough Prize in Life Sciences (2013)
  • Warren Triennial Prize (2014)[60][61]
  • Dr. Paul Janssen Award for Biomedical Research (2015)
  • Dan David Prize (2018)

Affiliations

  • Alpha Epsilon Delta (1968)
  • Phi Beta Kappa (1969)
  • The American Academy of Arts & Sciences (1992)
  • The National Academy of Sciences, USA (1992)
  • Alpha Omega Alpha (1995)
  • The American Philosophical Society (1995)
  • The Institute of Medicine (2001)
  • European Molecular Biology Organization (EMBO) (2005)

References

1. ^https://breakthroughprize.org/Laureates/2/L34
2. ^http://www.massgeneral.org/about/pressrelease.aspx?id=1766
3. ^Interview with Bert Vogelstein
4. ^{{cite journal | pmid = 2982210 | volume=227 | issue=4687 | title=Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors | journal=Science | pages=642–5 |vauthors=Vogelstein B, Fearon ER, Hamilton SR, Feinberg AP | doi=10.1126/science.2982210| year=1985 }}
5. ^{{cite journal | pmid = 2889267 | volume=238 | issue=4824 | title=Clonal analysis of human colorectal tumors | journal=Science | pages=193–7 |vauthors=Fearon ER, Hamilton SR, Vogelstein B | doi=10.1126/science.2889267| year=1987 }}
6. ^{{cite journal | pmid = 2841597 | doi=10.1056/NEJM198809013190901 | volume=319 | issue=9 | title=Genetic alterations during colorectal-tumor development | journal=N Engl J Med | pages=525–32 |author1=Vogelstein B |author2=Fearon ER |author3=Hamilton SR |author4=Kern SE |author5=Preisinger AC |author6=Leppert M |author7=Nakamura Y |author8=White R |author9=Smits AM |author10=Bos JL| year=1988 }}
7. ^{{cite journal | pmid = 2188735 | volume=61 | issue=5 | title=A genetic model for colorectal tumorigenesis | date=June 1990 | journal=Cell | pages=759–67 |vauthors=Fearon ER, Vogelstein B | doi=10.1016/0092-8674(90)90186-i}}
8. ^{{cite journal | pmid = 2649981 | volume=244 | issue=4901 | title=Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas | date=April 1989 | journal=Science | pages=217–21 |vauthors=Baker SJ, Fearon ER, Nigro JM, etal | doi=10.1126/science.2649981}}
9. ^{{cite journal | pmid = 2531845 | doi=10.1038/342705a0 | volume=342 | issue=6250 | title=Mutations in the p53 gene occur in diverse human tumour types | journal=Nature | pages=705–8 |vauthors=Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P| year=1989 }}
10. ^{{cite journal | pmid = 1301998 | volume=1 | issue=1 | title=Definition of a consensus binding site for p53.| date=April 1992 | journal=Nature Genetics | pages=45–49 |vauthors=el-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B | doi=10.1038/ng0492-45}}
11. ^1 {{cite journal | pmid = 1589764 | volume=256 | issue=5058 | title=Oncogenic forms of p53 inhibit p53-regulated gene expression | date=May 1992 | journal=Science | pages=827–30|author1=Kern SE |author2=Pietenpol JA |author3=Thiagalingam S |author4=Seymour A |author5=Kinzler KW |author6=Vogelstein B |doi=10.1126/science.1589764}}
12. ^{{cite journal | pmid = 8242752 | volume=75 | issue=4 | title=WAF1, a potential mediator of p53 tumor suppression.| date=November 1993 | journal=Cell | pages=817–825 |author1=el-Deiry WS |author2=Tokino T |author3=Velculescu VE |author4=Levy DB |author5=Parsons R |author6=Trent JM |author7=Lin D |author8=Mercer WE |author9=Kinzler KW |author10=Vogelstein B. |doi=10.1016/0092-8674(93)90500-P}}
13. ^{{cite journal | pmid = 11463391| volume=7 | issue=3 | title=PUMA induces the rapid apoptosis of colorectal cancer cells. | date=March 2001 | journal=Mol Cell | pages=673–82 |author1=Yu J |author2=Zhang L |author3=Hwang PM |author4=Kinzler KW |author5=Vogelstein B. | doi=10.1016/s1097-2765(01)00213-1}}
14. ^{{cite journal | pmid = 2047879 | volume=252 | issue=5013 | title=Identification of p53 as a sequence-specific DNA-binding protein | date=June 1991 | journal=Science | pages=1708–11 |vauthors=Kern SE, Kinzler KW, Bruskin A, etal | doi=10.1126/science.2047879}}
15. ^{{cite journal | pmid = 1301998 | doi=10.1038/ng0492-45 | volume=1 | title=Definition of a consensus binding site for p53 | journal=Nat Genet | pages=45–9 |vauthors=el-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B| year=1992 }}
16. ^{{cite journal | pmid = 8242752 | volume=75 | issue=4 | title=WAF1, a potential mediator of p53 tumor suppression | date=November 1993 | journal=Cell | pages=817–25 |vauthors=el-Deiry WS, Tokino T, Velculescu VE|display-authors=et al | doi=10.1016/0092-8674(93)90500-P}}
17. ^{{cite journal | pmid = 7585571 | volume=55 | issue=22 | title=p21 is necessary for the p53-mediated G1 arrest in human cancer cells | journal=Cancer Res | pages=5187–90 | author=Waldman T, Kinzler KW, Vogelstein B| year=1995 }}
18. ^{{cite journal | pmid = 12574499 | doi=10.1073/pnas.2627984100 | volume=100 | issue=4 | title=PUMA mediates the apoptotic response to p53 in colorectal cancer cells | pmc=149936 | date=February 2003 | journal=Proc. Natl. Acad. Sci. U.S.A. | pages=1931–6 | author=Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L}}
19. ^{{cite journal | pmid = 1651562 | volume=253 | issue=5020 | title=Identification of FAP locus genes from chromosome 5q21 | date=August 1991 | journal=Science | pages=661–5 |vauthors=Kinzler KW, Nilbert MC, Su LK, etal | doi=10.1126/science.1651562}}
20. ^{{cite journal | pmid = 1651563 | volume=253 | issue=5020 | title=Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients | date=August 1991 | journal=Science | pages=665–9 | vauthors=Nishisho I, Nakamura Y, Miyoshi Y|display-authors=et al | doi=10.1126/science.1651563}}
21. ^{{cite journal | pmid = 1528264 | doi=10.1038/359235a0 | volume=359 | issue=6392 | title=APC mutations occur early during colorectal tumorigenesis | journal=Nature | pages=235–7 |vauthors=Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B, Kinzler KW| year=1992 }}
22. ^{{cite journal | pmid = 8259519 | volume=262 | issue=5140 | title=Association of the APC tumor suppressor protein with catenins | date=December 1993 | journal=Science | pages=1734–7 |vauthors=Su LK, Vogelstein B, Kinzler KW | doi=10.1126/science.8259519}}
23. ^{{cite journal | pmid = 8484120 | volume=260 | issue=5109 | title=Genetic mapping of a locus predisposing to human colorectal cancer | journal=Science | pages=810–2 |vauthors=Peltomäki P, Aaltonen LA, Sistonen P, Pylkkänen L, Mecklin JP, Järvinen H, Green JS, Jass JR, Weber JL, Leach FS | doi=10.1126/science.8484120| year=1993 }}
24. ^{{cite journal | pmid = 8261515 | volume=75 | issue=6 | title=Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer | journal=Cell | pages=1215–25 |vauthors=Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomäki P, Sistonen P, Aaltonen LA, Nyström-Lahti M | doi=10.1016/0092-8674(93)90330-s| year=1993 }}
25. ^{{cite journal | pmid = 8128251 | volume=263 | issue=5153 | title=Mutation of a mutL homolog in hereditary colon cancer | date=March 1994 | journal=Science | pages=1625–9 |vauthors=Papadopoulos N, Nicolaides NC, Wei YF, etal | doi=10.1126/science.8128251}}
26. ^{{cite journal | pmid = 8072530 | doi=10.1038/371075a0 | volume=371 | issue=6492 | title=Mutations of two PMS homologues in hereditary nonpolyposis colon cancer | date=September 1994 | journal=Nature | pages=75–80 |vauthors=Nicolaides NC, Papadopoulos N, Liu B, etal}}
27. ^{{cite journal | pmid = 17932254 | doi=10.1126/science.1145720 | volume=318 | issue=5853 | title=The genomic landscapes of human breast and colorectal cancers | date=November 2007 | journal=Science | pages=1108–13 |vauthors=Wood LD, Parsons DW, Jones S, etal| citeseerx=10.1.1.218.5477 }}
28. ^{{cite journal | pmid = 15016963 | doi=10.1126/science.1096502 | volume=304 | issue=5670 | title=High frequency of mutations of the PIK3CA gene in human cancers | date=April 2004 | journal=Science | pages=554 |vauthors=Samuels Y, Wang Z, Bardelli A, etal}}
29. ^1 {{cite journal | pmid = 19228619 | doi=10.1056/NEJMoa0808710 | volume=360 | issue=8 | title=IDH1 and IDH2 mutations in gliomas | pmc=2820383 | date=February 2009 | journal=N. Engl. J. Med. | pages=765–73 |vauthors=Yan H, Parsons DW, Jin G, etal}}
30. ^{{cite journal | pmid = 20826764 | doi=10.1126/science.1196333 | volume=330 | issue=6001 | title=Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma | pmc=3076894 | journal=Science | pages=228–31 |vauthors=Jones S, Wang TL, Shih IeM Mao TL, Nakayama K, Roden R, Glas R, Slamon D, Diaz LA Jr, Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N| year=2010 }}
31. ^1 {{cite journal | pmid = 21252315 | doi=10.1126/science.1200609 | volume=331 | issue=6021 | title=DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors | pmc=3144496 | date=March 2011 | journal=Science | pages=1199–203 |vauthors=Jiao Y, Shi C, Edil BH, etal}}
32. ^{{cite journal | pmid = 18772397 | doi=10.1126/science.1164368 | volume=321 | issue=5897 | title=Core signaling pathways in human pancreatic cancers revealed by global genomic analyses | pmc=2848990 | date=September 2008 | journal=Science | pages=1801–6 |vauthors=Jones S, Zhang X, Parsons DW, etal}}
33. ^{{cite journal | pmid = 18772396 | doi=10.1126/science.1164382 | volume=321 | issue=5897 | title=An integrated genomic analysis of human glioblastoma multiforme | pmc=2820389 | date=September 2008 | journal=Science | pages=1807–12 |vauthors=Parsons DW, Jones S, Zhang X, etal}}
34. ^{{cite journal | pmid = 19264984 | doi=10.1126/science.1171202 | volume=324 | issue=5924 | title=Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene | pmc=2684332 | date=April 2009 | journal=Science | pages=217 |vauthors=Jones S, Hruban RH, Kamiyama M, etal}}
35. ^{{cite journal | pmid = 21817013 | doi=10.1126/science.1210557 | volume=333 | issue=6048 | title=Mutations in CIC and FUBP1 contribute to human oligodendroglioma | pmc=3170506 | journal=Science | pages=1453–5 |vauthors=Bettegowda C, Agrawal N, Jiao Y, Sausen M, Wood LD, Hruban RH, Rodriguez FJ, Cahill DP, McLendon R, Riggins G, Velculescu VE, Oba-Shinjo SM, Marie SK, Vogelstein B, Bigner D, Yan H, Papadopoulos N, Kinzler KW| year=2011 }}
36. ^{{cite journal | pmid = 2024123| volume=252 | issue=5006 | title=Identification of p53 gene mutations in bladder cancers and urine samples.| date=May 1991 | journal=Science | pages=706–709 |vauthors=Sidransky D, Von Eschenbach A, Tsai YC, Jones P, Summerhayes I, Marshall F, Paul M, Green P, Hamilton SR, Frost P|display-authors=et al |doi=10.1126/science.2024123}}
37. ^{{cite journal | pmid = 1566048| volume=7 | issue=5053 | title=Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. | date=March 2001 | journal=Science| pages=102–105 |author1=Sidransky D |author2=Tokino T |author3=Hamilton SR |author4=Kinzler KW |author5=Levin B |author6=Frost P |author7=Vogelstein B. | doi=10.1126/science.1566048}}
38. ^{{cite journal | pmid = 10430926 | volume=96 | issue=16 | title=Digital PCR | pmc=17763 | date=August 1999 | journal=Proc. Natl. Acad. Sci. U.S.A. | pages=9236–41 |vauthors=Vogelstein B, Kinzler KW | doi=10.1073/pnas.96.16.9236}}
39. ^{{cite journal | pmid = 12857956 | doi=10.1073/pnas.1133470100 | volume=100 | issue=15 | title=Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations | pmc=166396 | date=July 2003 | journal=Proc. Natl. Acad. Sci. U.S.A. | pages=8817–22 |vauthors=Dressman D, Yan H, Traverso G, Kinzler KW, Vogelstein B }}
40. ^{{cite journal | pmid = 16258065 | doi=10.1073/pnas.0507904102 | volume=102 | issue=45 | title=Detection and quantification of mutations in the plasma of patients with colorectal tumors.| date=November 2005 | journal=Proc. Natl. Acad. Sci. U.S.A. | pages=16368–73 |author1=Diehl F |author2=Li M |author3=Dressman D |author4=He Y |author5=Shen D |author6=Szabo S |author7=Diaz LA Jr |author8=Goodman SN |author9=David KA |author10=Juhl H |author11=Kinzler KW |author12=Vogelstein B. | pmc=1283450}}
41. ^{{cite journal |pmid=18670422 |doi=10.1038/nm.1789 | volume=14 |issue=9 | title=Circulating mutant DNA to assess tumor dynamics |date=September 2008 |journal=Nat. Med. | pages=985–90 |author1=Diehl F |author2=Schmidt K |author3=Choti MA |author4=Romans K |author5=Goodman S |author6=Li M |author7=Thornton K |author8=Agrawal N |author9=Sokoll L |author10=Szabo SA |author11=Kinzler KW |author12=Vogelstein B |author13=Diaz LA Jr. | pmc=2820391}}
42. ^{{cite journal | pmid = 23303603 | doi=10.1126/scitranslmed.3004952 | volume=5 | issue=167 | title=Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers |date=January 2013 | journal=Sci Transl Med |author1=Kinde I |author2=Bettegowda C |author3=Wang Y |author4=Wu J |author5=Agrawal N |author6=Shih IeM |author7=Kurman R |author8=Dao F |author9=Levine DA |author10=Giuntoli R |author11=Roden R |author12=Eshleman JR |author13=Carvalho JP |author14=Marie SK |author15=Papadopoulos N |author16=Kinzler KW |author17=Vogelstein B |author18=Diaz LA Jr. | pmc=3757513 | pages=167}}
43. ^{{cite journal | pmid = 24553385 | doi= 10.1126/scitranslmed.3007094 | volume=6 | issue= 224 | title=Detection of circulating tumor DNA in early- and late-stage human malignancies.| pmc=4017867 | date=February 2014 | journal=Sci Transl Med |author1=Bettegowda C |author2=Sausen M |author3=Leary RJ |author4=Kinde I |author5=Wang Y |author6=Agrawal N |author7=Bartlett BR |author8=Wang H |author9=Luber B |author10=Alani RM |author11=Antonarakis ES |author12=Azad NS |author13=Bardelli A |author14=Brem H |author15=Cameron JL |author16=Lee CC |author17=Fecher LA |author18=Gallia GL |author19=Gibbs P |author20=Le D |author21=Giuntoli RL |author22=Goggins M |author23=Hogarty MD |author24=Holdhoff M |author25=Hong SM |author26=Jiao Y |author27=Juhl HH |author28=Kim JJ |author29=Siravegna G |author30=Laheru DA |author31=Lauricella C |author32=Lim M |author33=Lipson EJ |author34=Marie SK |author35=Netto GJ |author36=Oliner KS |author37=Olivi A |author38=Olsson L |author39=Riggins GJ |author40=Sartore-Bianchi A |author41=Schmidt K |author42=Shih lM |author43=Oba-Shinjo SM |author44=Siena S |author45=Theodorescu D |author46=Tie J |author47=Harkins TT |author48=Veronese S |author49=Wang TL |author50=Weingart JD |author51=Wolfgang CL |author52=Wood LD |author53=Xing D |author54=Hruban RH |author55=Wu J |author56=Allen PJ |author57=Schmidt CM |author58=Choti MA |author59=Velculescu VE |author60=Kinzler KW |author61=Vogelstein B |author62=Papadopoulos N |author63=Diaz LA Jr. | page=224ra24}}
44. ^{{cite journal | pmid = 27384348 | doi=10.1126/scitranslmed.aaf6219 | volume=8 | issue=346 | title=Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer | date=July 2016 | journal=Sci Transl Med |author1=Tie J |author2=Wang Y |author3=Tomasetti C |author4=Li L |author5=Springer S |author6=Kinde I |author7=Silliman N |author8=Tacey M |author9=Wong HL |author10=Christie M |author11=Kosmider S |author12=Skinner I |author13=Wong R |author14=Steel M |author15=Tran B |author16=Desai J |author17=Jones I |author18=Haydon A |author19=Hayes T |author20=Price TJ |author21=Strausberg RL |author22=Diaz LA Jr |author23=Papadopoulos N |author24=Kinzler KW |author25=Vogelstein B |author26=Gibbs P. | pmc=5346159 | page=346ra92}}
45. ^{{cite journal|author=Diaz|title=The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers|journal=Nature|date=June 28, 2012|volume=486|issue=7404|pages=537–540|doi=10.1038/nature11219|pmid=22722843|display-authors=etal|pmc=3436069}}
46. ^{{cite journal|author=Bozic|author2=Reiter|author3=Allen|title=Evolutionary dynamics of cancer in response to targeted combination therapy|journal=eLife|date=June 25, 2013|volume=2 | issue=e00747|pages=e00747|doi=10.7554/eLife.00747|pmid=23805382|pmc=3691570|display-authors=etal}}
47. ^{{cite website |url=http://www.webometrics.info/en/node/58 |title=1360 Highly Cited Researchers (h>100) according to their Google Scholar Citations public profiles |accessdate=1 February 2017}}
48. ^Bristol Myers Squibb Award
49. ^{{cite web |title=Past Recipients / Bert Vogelstein |work=Canada Gairdner Award web site |url=http://www.gairdner.org/content/bert-vogelstein}}
50. ^[https://www.bcps.org/students/alumni/BVogelstein_full_bio.html Team BCPS: creating a culture of deliberate excellence, Baltimore County Public Schools]
51. ^Pezcoller Foundation Award
52. ^[https://www.aamc.org/download/374972/data/ar_1992-1993.pdf Baxter Award]
53. ^Passano Award
54. ^[https://web.archive.org/web/20150402091042/http://www.asco.org/about-asco/david-karnofsky-memorial-award-and-lecture David A. Karnofsky Memorial Award]
55. ^[https://web.archive.org/web/20150402160613/http://www.gastro.org/community/awards-nominations/member-recognition-prizes/william-beaumont-prize-in-gastroenterology William Beaumont Prize]
56. ^{{cite web |title=John Scott Award recipients |url=http://www.garfield.library.upenn.edu/johnscottaward(full).html |deadurl=yes |archiveurl=https://web.archive.org/web/20100701201455/http://www.garfield.library.upenn.edu/johnscottaward%28full%29.html |archivedate=2010-07-01 |df= }}
57. ^{{cite web |title=Prince of Asturias Award for Technical & Scientific Research 2004 |url=http://www.fpa.es/en/prince-of-asturias-awards/awards/2004-scientists-at-the-forefront-of-the-fight-against-cancer.html?especifica=0}}
58. ^{{cite web |title=Cancer Research Prize |publisher=Charles Rodolphe Brupbacher Foundation |url=http://www.brupbacher-foundation.org/index.php/cancer-research-prize |deadurl=yes |archiveurl=https://web.archive.org/web/20150403210351/http://www.brupbacher-foundation.org/index.php/cancer-research-prize |archivedate=2015-04-03 |df= }}
59. ^Clowes Memorial Award
60. ^http://www.massgeneral.org/about/pressrelease.aspx?id=1766
61. ^Warren Triennial Prize

External links

  • The Official Site of Louisa Gross Horwitz Prize
  • Howard Hughes Medical Institute Bio
  • [https://web.archive.org/web/20051222042026/http://www.sciencewatch.com/interviews/bert_vogelstein1.htm Science watch interview]
{{Breakthrough Prize laureates}}{{Authority control}}{{DEFAULTSORT:Vogelstein, Bert}}

12 : Howard Hughes Medical Investigators|Members of the United States National Academy of Sciences|Johns Hopkins Hospital physicians|American oncologists|1949 births|Members of the European Molecular Biology Organization|Living people|People from Baltimore County, Maryland|University of Pennsylvania alumni|Johns Hopkins School of Medicine alumni|American Jews|Breakthrough Prize winners
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