- Structural studies
- References
| Name = beta-phosphoglucomutase
| EC_number = 5.4.2.6
| CAS_number = 68651-99-0
| IUBMB_EC_number = 5/4/2/6
| GO_code = 0008801
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In enzymology, a beta-phosphoglucomutase ({{EC number|5.4.2.6}}) is an enzyme that catalyzes the chemical reaction
beta-D-glucose 1-phosphatebeta-D-glucose 6-phosphate
Hence, this enzyme has one substrate, beta-D-glucose 1-phosphate, and one product, beta-D-glucose 6-phosphate.
This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is beta-D-glucose 1,6-phosphomutase. This enzyme participates in starch and sucrose metabolism.
Structural studies
20 structures have been solved for this enzyme PDB. Some of the accession codes are {{PDB link|1LVH}}, {{PDB link|1O03}}, {{PDB link|1O08}}, {{PDB link|1Z4N}}, {{PDB link|1Z4O}}, and {{PDB link|1ZOL}}. Most of these structures detail metal fluoride analogue complexes which are used to mimic different states along the reaction coordinate.
References
- {{cite journal | vauthors = Ben-Zvi R, Schramm M | date = 1961 | title = A phosphoglucomutase specific for beta-glucose 1-phosphate | journal = J. Biol. Chem. | volume = 236 | pages = 2186–2189 }}
- {{cite book | veditors = Boyer PD | title = The Enzymes | edition = 3rd | volume = 6 | date = 1972 | pages = 407–477 }}