“Bis(5'-adenosyl)-triphosphatase”的意思、由来-开放百科全书

词条

Bis(5'-adenosyl)-triphosphatase

释义

Structural studies
References

{{enzyme
| Name = bis(5'-adenosyl)-triphosphatase
| EC_number = 3.6.1.29
| CAS_number = 63951-94-0
| IUBMB_EC_number = 3/6/1/29
| GO_code = 0047710
| image =
| width =
| caption =
}}

In enzymology, a bis(5'-adenosyl)-triphosphatase ({{EC number|3.6.1.29}}) is an enzyme that catalyzes the chemical reaction

P₁,P₃-bis(5'-adenosyl) triphosphate + H₂O ADP + AMP

Thus, the two substrates of this enzyme are P1,P3-bis(5'-adenosyl) triphosphate and H₂O, whereas its two products are ADP and AMP.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase. Other names in common use include dinucleosidetriphosphatase, diadenosine 5,5-P1,P3-triphosphatase, and 1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase. This enzyme participates metabolic pathways involved in purine metabolism, and may have a role in the development of small cell lung cancer, and non-small cell lung cancer.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1FHI}}, {{PDB link|2FHI}}, {{PDB link|4FIT}}, {{PDB link|5FIT}}, and {{PDB link|6FIT}}.

References

{{cite journal |vauthors=Jakubowski H, Guranowski A | date = 1983 | title = Enzymes hydrolyzing ApppA and/or AppppA in higher plants Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds | journal = J. Biol. Chem. | volume = 258 | pages = 9982–9 | pmid = 6309793 | issue = 16 }}
{{cite journal | author = A | date = 1977 | title = Dinucleosidetriphosphatase from rat liver. Purification and properties | journal = Eur. J. Biochem. | volume = 76 | pages = 331–7 | pmid = 196848 | doi = 10.1111/j.1432-1033.1977.tb11600.x | last2 = Villalba | first2 = R | last3 = Moreno | first3 = A | last4 = Quintanilla | first4 = M | last5 = Lobatón | first5 = CD | last6 = Sillero | first6 = A | issue = 2 }}

2 : EC 3.6.1|Enzymes of known structure

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