“Bisoctrizole”的意思、由来-开放百科全书

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Bisoctrizole (INN^[1]/USAN,^[2] marketed by BASF as Tinosorb M and by MPI as Milestab 360, INCI methylene bis-benzotriazolyl tetramethylbutylphenol) is a benzotriazole-based organic compound that is added to sunscreens to absorb UV rays.

Bisoctrizole is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. It also reflects and scatters UV. Bisoctrizole is a hybrid UV absorber, the only organic UV filter produced in microfine organic particles (< 200 nm),^[3]^[4] like microfine zinc oxide and titanium dioxide. Where other organic UV absorbers need to be dissolved in either the oil or water phase, bisoctrizole dissolves poorly in both.

Bisoctrizole is added to the water phase of a sunscreen as a 50% suspension, whereas mineral micropigments are usually added to the oil phase. The bisoctrizole particles are stabilized by the surfactant decyl glucoside.

Bisoctrizole shows very little photodegradation and has a stabilizing effect on other UV absorbers, octyl methoxycinnamate (octinoxate) in particular.

When formulated into a sunscreen, bisoctrizole has minimal skin penetration.^[5] Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro.^[6]

Bisoctrizole is not approved by the U.S. Food and Drug Administration (FDA), but is approved in the EU and other parts of the world.^[7]^[8]^[9]

References

1. ^{{cite web | url = http://apps.who.int/medicinedocs/en/d/Js7918e/8.html | title = International Nonproprietary Names for Pharmaceutical Substances (INN) | publisher = World Health Organization}}
2. ^http://www.ama-assn.org/ama1/pub/upload/mm/365/bisoctrizol.doc {{dead link|date=January 2019}}
3. ^Ciba TINOSORB M
4. ^{{cite journal | doi = 10.1046/j.1467-2494.2002.00137.x | title = In vivo and in vitro assessment of UVA protection by sunscreen formulations containing either butyl methoxy dibenzoyl methane, methylene bis-benzotriazolyl tetramethylbutylphenol, or microfine ZnO | year = 2002 | last1 = Herzog | first1 = B. | last2 = Mongiat | first2 = S. | last3 = Deshayes | first3 = C. | last4 = Neuhaus | first4 = M. | last5 = Sommer | first5 = K. | last6 = Mantler | first6 = A. | journal = International Journal of Cosmetic Science | volume = 24 | issue = 3 | pages = 170–85 | pmid = 18498509 }}
5. ^{{cite journal| title=In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen| year=2007| pmid=17035717|vauthors=Mavon A, Miquel C, Lejeune O, Payre B, Moretto P | journal=Skin Pharmacol Physiol| volume=20 | pages=10–20| doi=10.1159/000096167| issue=1}}
6. ^{{cite journal| title=Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S|date=December 2001| pmid=11754532|vauthors=Ashby J, Tinwell H, Plautz J, Twomey K, Lefevre PA | journal= Regul Toxicol Pharmacol| volume=34 | pages=287–91| doi=10.1006/rtph.2001.1511| issue=3}}
7. ^Manage Account - Modern Medicine
8. ^CL1976L0768EN0150010.0001 1..107
9. ^Australian Regulatory Guidelines for OTC Medicines - Chapter 10 {{webarchive|url=https://web.archive.org/web/20070831075404/http://tga.gov.au/docs/pdf/argom_10.pdf |date=2007-08-31 }}

References

External links