| 词条 | Bisthiosemicarbazone |
| 释义 |
In organic chemistry, a bisthiosemicarbazone is a derivative from an elimination reaction between a thiosemicarbazide and a diketone. Their structure is H2NHC(=S)NN=C(R1)-R2-C(R3)=NNHC(=S)NH2. A 'thiosemicarbazone' contains a sulfur atom in lieu of the ketonic oxygen in semicarbazone. Bisthiosemicarbazones are known to have anti-viral, anti-malarial and anti-cancer activity,[1] usually mediated through binding to copper or iron in cells. They have also been identified as potential ligands for radioisotope delivery, with selectivity towards hypoxic tissues, particularly in the heart and brain.[2][3][4] When chelated to zinc atoms some bisthiosemicarbazones may have uses as fluorescing agents in optical microscopy. See also
References1. ^{{cite journal|last1=Palanimuthu|first1=Duraippandi|last2=Shinde|first2=Sridevi Vijay|last3=Somasundaram|first3=Kumaravel|last4=Samuelson|first4=Ashoka G.|title=In Vitro and in Vivo Anticancer Activity of Copper Bis(thiosemicarbazone) Complexes|journal=Journal of Medicinal Chemistry|date=14 February 2013|volume=56|issue=3|pages=722–734|doi=10.1021/jm300938r|pmid=23320568}} {{Organic-chemistry-stub}}2. ^{{cite journal|last1=Dearling|first1=Jason L.|last2=Lewis|first2=Jason S.|last3=Mullen|first3=Gregory E.|last4=Welch|first4=Michael J.|last5=Blower|first5=Philip J.|title=Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships|journal=JBIC Journal of Biological Inorganic Chemistry|date=20 April 2014|volume=7|issue=3|pages=249–259|doi=10.1007/s007750100291}} 3. ^{{cite journal|last1=Maurer|first1=Richard I.|last2=Blower|first2=Philip J.|last3=Dilworth|first3=Jonathan R.|last4=Reynolds|first4=Christopher A.|last5=Zheng|first5=Yifan|last6=Mullen|first6=Gregory E. D.|title=Studies on the Mechanism of Hypoxic Selectivity in Copper Bis(Thiosemicarbazone) Radiopharmaceuticals|journal=Journal of Medicinal Chemistry|date=March 2002|volume=45|issue=7|pages=1420–1431|doi=10.1021/jm0104217}} 4. ^{{cite journal|last1=Cowley|first1=Andrew R.|last2=Dilworth|first2=Jonathan R.|last3=Donnelly|first3=Paul S.|last4=Labisbal|first4=Elena|last5=Sousa|first5=Antonio|title=An Unusual Dimeric Structure of a Cu(I) Bis(thiosemicarbazone) Complex: Implications for the Mechanism of Hypoxic Selectivity of the Cu(II) Derivatives|journal=Journal of the American Chemical Society|date=May 2002|volume=124|issue=19|pages=5270–5271|doi=10.1021/ja012668z}} 3 : Functional groups|Thiocarbonyl compounds|Thiosemicarbazone |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。