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词条 Bombesin-like receptor 3
释义

  1. Function

  2. References

  3. Further reading

  4. External links

{{Infobox_gene}}

The bombesin receptor subtype 3 also known as BRS-3 or BB3[1] is a protein which in humans is encoded by the BRS3 gene.[2][3]

Function

Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[3][4]

BB3 is a G protein-coupled receptor.[2] BB3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[2][5][6]

References

1. ^{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2958 | title = Bombesin Receptors: BB3 | accessdate = | date = | format = | website = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
2. ^1 2 {{cite journal | vauthors = Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF | title = BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells | journal = J. Biol. Chem. | volume = 268 | issue = 8 | pages = 5979–84 |date=March 1993 | pmid = 8383682 | doi = | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=8383682 | issn = }}
3. ^1 {{cite journal | vauthors = Ohki-Hamazaki H, Wada E, Matsui K, Wada K | title = Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse | journal = Brain Res. | volume = 762 | issue = 1–2 | pages = 165–72 |date=July 1997 | pmid = 9262170 | doi = 10.1016/S0006-8993(97)00380-6| url = }}
4. ^{{cite web | title = Entrez Gene: BRS3 bombesin-like receptor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=680| accessdate = }}
5. ^{{cite journal | vauthors = Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT | last-author-amp = yes | title = Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors | journal = J. Biol. Chem. | volume = 272 | issue = 41| pages = 26062–26071 | year = 1997 | pmid = 9325344 | doi = 10.1074/jbc.272.41.26062| url = }}
6. ^{{cite journal | vauthors = Jensen RT, Battey JF, Spindel ER, Benya RV | last-author-amp = yes | title = International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states | journal = Pharmacol. Rev. | volume = 60 | issue = 1| pages = 1–42 | year = 2007 | pmid = 18055507 | doi = 10.1124/pr.107.07108| url = | pmc = 2517428 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F |title=Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus |journal=FEBS Lett. |volume=340 |issue= 3 |pages= 260–4 |year= 1994 |pmid= 8131855 |doi=10.1016/0014-5793(94)80150-9 }}
  • {{cite journal | vauthors=Fathi Z, Corjay MH, Shapira H |title=BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells |journal=J. Biol. Chem. |volume=268 |issue= 8 |pages= 5979–84 |year= 1993 |pmid= 8383682 |doi= |display-authors=etal}}
  • {{cite journal | vauthors=Kane MA, Toi-Scott M, Johnson GL |title=Bombesin-like peptide receptors in human bronchial epithelial cells |journal=Peptides |volume=17 |issue= 1 |pages= 111–8 |year= 1996 |pmid= 8822519 |doi=10.1016/0196-9781(95)02088-8 |display-authors=etal}}
  • {{cite journal | vauthors=Ohki-Hamazaki H, Watase K, Yamamoto K |title=Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity |journal=Nature |volume=390 |issue= 6656 |pages= 165–9 |year= 1997 |pmid= 9367152 |doi= 10.1038/36568 |display-authors=etal}}
  • {{cite journal | vauthors=Ryan RR, Weber HC, Hou W |title=Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3 |journal=J. Biol. Chem. |volume=273 |issue= 22 |pages= 13613–24 |year= 1998 |pmid= 9593699 |doi=10.1074/jbc.273.22.13613 |display-authors=etal}}
  • {{cite journal | vauthors=Liu J, Lao ZJ, Zhang J |title=Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3) |journal=Biochemistry |volume=41 |issue= 28 |pages= 8954–60 |year= 2002 |pmid= 12102638 |doi=10.1021/bi0202777 |display-authors=etal}}
  • {{cite journal | vauthors=Ross MT, Grafham DV, Coffey AJ |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 |display-authors=etal}}
  • {{cite journal | vauthors=Hou X, Wei L, Harada A, Tatamoto K |title=Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells |journal=Lung Cancer |volume=54 |issue= 2 |pages= 143–8 |year= 2007 |pmid= 16979789 |doi= 10.1016/j.lungcan.2006.08.005 }}
  • {{cite journal | vauthors=Tan YR, Qin XQ, Xiang Y |title=PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells |journal=Biochem. J. |volume=405 |issue= 1 |pages= 131–7 |year= 2007 |pmid= 17355223 |doi= 10.1042/BJ20061754 | pmc=1925247 |display-authors=etal}}
{{refend}}

External links

  • {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2958 | title = Bombesin Receptors: BB3 | accessdate = | date = | format = | website = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
  • {{MeshName|bombesin+receptor+subtype+3}}
  • {{UCSC gene info|BRS3}}
{{NLM content}}{{G protein-coupled receptors}}{{transmembranereceptor-stub}}

1 : G protein-coupled receptors
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